Progressive multifocal leucoencephalopathy associated with lupus and methotrexate overdose

Progressive multifocal leucoencephalopathy (PML) is a CNS infection of oligodendrocytes by JC virus, which rarely occurs in lupus, and can be mistaken for antiphospholipid antibody syndrome or neuropsychiatric systemic lupus erythematosus (NSLE). This case of PML in a patient with systemic lupus ery...

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Bibliographic Details
Published in:Lupus 2008-11, Vol.17 (11), p.1029-1032
Main Authors: Shprecher, D, Frech, T, Chin, S, Eskandari, R, Steffens, J
Format: Article
Language:English
Subjects:
Drug Overdose
Female
Humans
JC virus
Leukoencephalopathy, Progressive Multifocal - complications
Leukoencephalopathy, Progressive Multifocal - diagnosis
Lupus Erythematosus, Systemic - complications
Methotrexate - adverse effects
Middle Aged
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Summary:Progressive multifocal leucoencephalopathy (PML) is a CNS infection of oligodendrocytes by JC virus, which rarely occurs in lupus, and can be mistaken for antiphospholipid antibody syndrome or neuropsychiatric systemic lupus erythematosus (NSLE). This case of PML in a patient with systemic lupus erythematosus on supra-therapeutic doses of methotrexate emphasises that CNS infection is an important diagnostic consideration before empiric treatment with immunosuppresants for NSLE.
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203308089435