Synthesis and biological activity of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and their reduction products

A series of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and products of their reduction has been synthesized and their pharmacological properties have been studied. Most of the synthesized substances possess weak antioxidant activity. At...

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Published in:Pharmaceutical chemistry journal 2006-05, Vol.40 (5), p.261-267
Main Authors: Anisimova, V. A., Tolpygin, I. E., Spasov, A. A., Kosolapov, V. A., Stepanov, A. V., Kucheryavenko, A. F.
Format: Article
Language:English
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Summary:A series of N-acylmethyl derivatives of 9H-2,3-dihydroimidazo-and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles and products of their reduction has been synthesized and their pharmacological properties have been studied. Most of the synthesized substances possess weak antioxidant activity. At the same time, they exhibit pronounced antiaggregant and hemorheological properties, possess spasmolytic activity, and influence the blood glucose level.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-006-0105-8