Manganese-Catalyzed Intermolecular Oxidative Annulation of Alkynes with γ‑Vinyl Aldehydes: An Entry to Bridged Carbocyclic Systems

Manganese-catalyzed intermolecular oxidative annulation of alkynes with γ-vinyl aldehydes involving acylation and alkylation is described, thus providing a scenario for the divergent synthesis of bridged carbocyclic systems. By means of this manganese-catalyzed alkyne dicarbofunctionalization strate...

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Bibliographic Details
Published in:Organic letters 2017-11, Vol.19 (22), p.6172-6175
Main Authors: Li, Yang, Li, Jin-Xia, Ouyang, Xuan-Hui, Wang, Qiu-An, Li, Jin-Heng
Format: Article
Language:English
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Summary:Manganese-catalyzed intermolecular oxidative annulation of alkynes with γ-vinyl aldehydes involving acylation and alkylation is described, thus providing a scenario for the divergent synthesis of bridged carbocyclic systems. By means of this manganese-catalyzed alkyne dicarbofunctionalization strategy, three chemical bonds, including two C–C bonds and one C–H bond, are formed via an aldehyde C­(sp2)–H oxidative functionalization/[4 + 2] annulation/protonation cascade.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b03086