Effective excision of cutaneous squamous cell carcinoma of the face using analysis of intra‐operative frozen sections from the whole specimen

Background and Objectives We excised cutaneous squamous cell carcinoma (cSCC) of the face while using intra‐operative frozen section analysis of the margins in an optimized bread‐loafing fashion (WIFSA). Methods Medical records were reviewed of 160 cSCCs of the face that were treated by surgical exc...

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Bibliographic Details
Published in:Journal of surgical oncology 2018-03, Vol.117 (3), p.473-478
Main Authors: Hutting, Kor H., Bos, Paul G., Kibbelaar, Robby E., Veeger, Nic J. G. M., Marck, Klaas W., Mouës, Chantal M.
Format: Article
Language:English
Subjects:
Aged
Cancer surgery
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
cutaneous malignancies
Facial Neoplasms - pathology
Facial Neoplasms - surgery
Female
Frozen Sections
Head & neck cancer
Humans
Male
margin analysis
Margins of Excision
Metastasis
Mohs micrographic surgery
Monitoring, Intraoperative - methods
Neoplasm Recurrence, Local - pathology
Retrospective Studies
Skin cancer
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Squamous cell carcinoma
Treatment Outcome
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Summary:Background and Objectives We excised cutaneous squamous cell carcinoma (cSCC) of the face while using intra‐operative frozen section analysis of the margins in an optimized bread‐loafing fashion (WIFSA). Methods Medical records were reviewed of 160 cSCCs of the face that were treated by surgical excision with WIFSA between April 2007 and January 2013. The accuracy of WIFSA was verified by comparing results with postoperative formalin‐fixed paraffin‐embedded (FFPE) sections. Also, recurrence and metastasis during follow‐up were studied and duration of treatment and complications were analyzed. Results The 160 cSCCs affected 152 patients. In 131 cSCCs (mean follow‐up: 41.0 months, SD: ±26.3, range: 3.0‐110.7) occurred 6 (4.6%) recurrences and 2 (1.5%) metastases. Of the WIFSA results, 98.8% corresponded with postoperative FFPE sections. Mean duration of treatment was 77 min (SD: ±25, range: 34‐159) and complication rate was 8.1%. Conclusions Surgical excision with WIFSA is an excellent treatment modality for cSCC of the face because of its accurate method for assessment of complete tumor removal, low recurrence and metastasis rate, short average duration of treatment, and low complication rate.
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.24870