Ciprofloxacin vs levofloxacin for prophylaxis during hematopoietic stem‐cell transplantation

The objective of the current retrospective study was to compare differences in rate of breakthrough infections for ciprofloxacin vs levofloxacin prophylaxis in autologous hematopoietic stem‐cell transplant (HSCT) patients treated for multiple myeloma. This was a retrospective, cohort study comparing...

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Bibliographic Details
Published in:Clinical transplantation 2018-01, Vol.32 (1), p.n/a
Main Authors: Copeland, Vanessa, McLaughlin, Milena, Trifilio, Steven
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Antibiotic Prophylaxis
antimicrobial prophylaxis
Bacterial Infections - epidemiology
Bacterial Infections - microbiology
Bacterial Infections - prevention & control
Ciprofloxacin - therapeutic use
Female
fluoroquinolones
Follow-Up Studies
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Incidence
infection
Levofloxacin - therapeutic use
Male
Middle Aged
Multiple Myeloma - therapy
Prognosis
Retrospective Studies
stem‐cell transplantation
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Summary:The objective of the current retrospective study was to compare differences in rate of breakthrough infections for ciprofloxacin vs levofloxacin prophylaxis in autologous hematopoietic stem‐cell transplant (HSCT) patients treated for multiple myeloma. This was a retrospective, cohort study comparing autologous HSCT recipients treated for multiple myeloma who received ciprofloxacin prophylaxis vs levofloxacin prophylaxis. A total of 297 patients, 143 levofloxacin‐ and 154 ciprofloxacin‐treated were included. There was a significantly higher incidence of bloodstream infections in the ciprofloxacin group (24/154) compared to the levofloxacin group (10/143), P = .03, primarily caused by a statistically higher incidence of gram‐positive bloodstream infections (ciprofloxacin [21/154] vs levofloxacin [8/143]; P 
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.13145