Triblock peptide-oligonucleotide chimeras (POCs): programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materials

Triblock peptide-oligonucleotide chimeras (POCs) consisting of peptides and oligonucleotides interlinked by an organic core are presented and their assembly behaviour is investigated. Several factors influence POC assembly, resulting in the formation of either vesicles or fibres. Design rules are in...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (90), p.12221-12224
Main Authors: Merg, Andrea D, Thaner, Ryan V, Mokashi-Punekar, Soumitra, Nguyen, SonBinh T, Rosi, Nathaniel L
Format: Article
Language:English
Subjects:
Assembly
Biomolecules
Oligonucleotides
Peptides
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Summary:Triblock peptide-oligonucleotide chimeras (POCs) consisting of peptides and oligonucleotides interlinked by an organic core are presented and their assembly behaviour is investigated. Several factors influence POC assembly, resulting in the formation of either vesicles or fibres. Design rules are introduced and used to predict and alter POC assembly morphology.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc07708d