Novel and facile synthesis of 1-benzazepines via copper-catalyzed oxidative C(sp 3 )-H/C(sp 2 )-H cross-coupling

A novel and facile synthetic strategy for the construction of 1-benzazepines has been developed via copper-catalyzed oxidative C(sp )-H/C(sp )-H cross-coupling directly from two inert C-H bonds. This transformation represents an atom- and step-economical way to synthesize biologically important seve...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (90), p.12229-12232
Main Authors: Wang, Rui, Jin, Ruo-Xing, Qin, Zi-Yang, Bian, Kang-Jie, Wang, Xi-Sheng
Format: Article
Language:English
Subjects:
Chemical synthesis
Copper
Coupling
Cross coupling
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Summary:A novel and facile synthetic strategy for the construction of 1-benzazepines has been developed via copper-catalyzed oxidative C(sp )-H/C(sp )-H cross-coupling directly from two inert C-H bonds. This transformation represents an atom- and step-economical way to synthesize biologically important seven-membered benzo-heterocycles compared with the known methods.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc07027f