Insulin-like growth factor-6 (IGFBP-6) stimulates neutrophil oxidative burst, degranulation and chemotaxis

The aim of this study was to understand whether insulin-like growth factor-binding protein-6 (IGFBP-6) has functional effects on neutrophils, in particular when they cross epithelium during inflammation. We found that IGFBP-6 increased ROS production (cytofluorimetry), degranulation of primary and t...

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Bibliographic Details
Published in:Inflammation research 2018-02, Vol.67 (2), p.107-109
Main Authors: Conese, Massimo, D’Oria, Susanna, Castellani, Stefano, Trotta, Rosa, Montemurro, Pasqualina, Liso, Arcangelo
Format: Article
Language:English
Subjects:
Allergology
Biomedical and Life Sciences
Biomedicine
Cell Degranulation - drug effects
Cell migration
Chemotaxis
Chemotaxis - drug effects
Cytoplasmic Granules - drug effects
Degranulation
Dermatology
Enzyme-linked immunosorbent assay
Epithelium
Formyl peptides
Humans
Immunology
In Vitro Techniques
Insulin
Insulin-Like Growth Factor Binding Protein 6 - pharmacology
Insulin-like growth factor-binding protein 6
Insulin-like growth factors
Leukocytes (neutrophilic)
Matrix Metalloproteinase 9 - metabolism
Neurology
Neutrophils
Neutrophils - drug effects
Peroxidase - analysis
Peroxidase - metabolism
Pharmacology/Toxicology
Physical growth
Priming
Reactive Oxygen Species - metabolism
Respiratory Burst - drug effects
Rheumatology
Short Communication
Signal Transduction
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Summary:The aim of this study was to understand whether insulin-like growth factor-binding protein-6 (IGFBP-6) has functional effects on neutrophils, in particular when they cross epithelium during inflammation. We found that IGFBP-6 increased ROS production (cytofluorimetry), degranulation of primary and tertiary granules (ELISA) and transmigration through the epithelial monolayer. No priming by IGFBP-6 on neutrophils stimulated by either PMA or fMLP was observed. IGFBP-6 is an agonist of neutrophils’ functions, most likely when these cells have been already activated by other stimuli.
ISSN:1023-3830
1420-908X
DOI:10.1007/s00011-017-1107-6