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Immunogenicity and Safety of Yellow Fever Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients After Withdrawal of Immunosuppressive Therapy
Yellow fever (YF) vaccine appears safe and immunogenic in selected hematopoietic stem cell transplant recipients. Persistent immunity to YF vaccine is observed in some patients vaccinated before transplantation and/or vaccinated with an immunized donor. Immunity to YF should be evaluated prior to va...
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Published in: | The Journal of infectious diseases 2018-01, Vol.217 (3), p.494-497 |
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container_end_page | 497 |
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container_title | The Journal of infectious diseases |
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creator | Sicre de Fontbrune, Flore Arnaud, Cécile Cheminant, Morgane Boulay, Aude Konopacki, Johana Lapusan, Simona Robin, Christine Bernaudin, Françoise Suarez, Felipe Simon, François Socié, Gérard Colin de Verdière, Nathalie Consigny, Paul-Henri |
description | Yellow fever (YF) vaccine appears safe and immunogenic in selected hematopoietic stem cell transplant recipients. Persistent immunity to YF vaccine is observed in some patients vaccinated before transplantation and/or vaccinated with an immunized donor. Immunity to YF should be evaluated prior to vaccination.
Abstract
As a live attenuated vaccine, yellow fever vaccine (YFV) is not routinely performed after allogeneic hematopoietic stem cell transplant (HSCT) despite it being the only efficient preventive therapy. We retrospectively identified 21 HSCT recipients immunized with YFV at a median of 39 months after HSCT and a median of 33 months after withdrawal of immunosuppression without any side effects. Eighteen evaluable patients had protective immunity after YFV. We also observed that a third of the recipients vaccinated with YFV before HSCT had persistent protective immunity after HSCT. |
doi_str_mv | 10.1093/infdis/jix564 |
format | article |
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Abstract
As a live attenuated vaccine, yellow fever vaccine (YFV) is not routinely performed after allogeneic hematopoietic stem cell transplant (HSCT) despite it being the only efficient preventive therapy. We retrospectively identified 21 HSCT recipients immunized with YFV at a median of 39 months after HSCT and a median of 33 months after withdrawal of immunosuppression without any side effects. Eighteen evaluable patients had protective immunity after YFV. We also observed that a third of the recipients vaccinated with YFV before HSCT had persistent protective immunity after HSCT.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jix564</identifier><identifier>PMID: 29087520</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><ispartof>The Journal of infectious diseases, 2018-01, Vol.217 (3), p.494-497</ispartof><rights>The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2017</rights><rights>The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-a8b0775d5dda02a2e61b62346e221e29ca1a8008121587d541ecedbeacec391a3</citedby><cites>FETCH-LOGICAL-c365t-a8b0775d5dda02a2e61b62346e221e29ca1a8008121587d541ecedbeacec391a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29087520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sicre de Fontbrune, Flore</creatorcontrib><creatorcontrib>Arnaud, Cécile</creatorcontrib><creatorcontrib>Cheminant, Morgane</creatorcontrib><creatorcontrib>Boulay, Aude</creatorcontrib><creatorcontrib>Konopacki, Johana</creatorcontrib><creatorcontrib>Lapusan, Simona</creatorcontrib><creatorcontrib>Robin, Christine</creatorcontrib><creatorcontrib>Bernaudin, Françoise</creatorcontrib><creatorcontrib>Suarez, Felipe</creatorcontrib><creatorcontrib>Simon, François</creatorcontrib><creatorcontrib>Socié, Gérard</creatorcontrib><creatorcontrib>Colin de Verdière, Nathalie</creatorcontrib><creatorcontrib>Consigny, Paul-Henri</creatorcontrib><title>Immunogenicity and Safety of Yellow Fever Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients After Withdrawal of Immunosuppressive Therapy</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Yellow fever (YF) vaccine appears safe and immunogenic in selected hematopoietic stem cell transplant recipients. Persistent immunity to YF vaccine is observed in some patients vaccinated before transplantation and/or vaccinated with an immunized donor. Immunity to YF should be evaluated prior to vaccination.
Abstract
As a live attenuated vaccine, yellow fever vaccine (YFV) is not routinely performed after allogeneic hematopoietic stem cell transplant (HSCT) despite it being the only efficient preventive therapy. We retrospectively identified 21 HSCT recipients immunized with YFV at a median of 39 months after HSCT and a median of 33 months after withdrawal of immunosuppression without any side effects. Eighteen evaluable patients had protective immunity after YFV. We also observed that a third of the recipients vaccinated with YFV before HSCT had persistent protective immunity after HSCT.</description><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFUU1v1DAQtRCILoUjV-Qjl1DbWSfOcbWitFIlJLq04hTN2hPqKrGN7bTsb-mfxVUKHHuaD715b2YeIe85-8RZV59YNxibTm7tb9msX5AVl3VbNQ2vX5IVY0JUXHXdEXmT0i1jbF037WtyJDqmWinYijycT9Ps_E90Vtt8oOAMvYQBS-oH-gPH0d_TU7zDSK9Aa-uQWkc3pV1G0Gp6hhNkH7zFXKrLjBPdlim6i-BSGMFl-g21DRZdTnQz5MJ0bfONiXAP46PIskGaQ4iYkr1DurvBCOHwlrwaYEz47ikek--nn3fbs-ri65fz7eai0nUjcwVqz9pWGmkMMAECG75vRL1uUAiOotPAQTGmuOBStUauOWo0ewSNuu441Mfk48Ibov81Y8r9ZJMuR4BDP6eed1KVr7ZKFWi1QHX0KUUc-hDtBPHQc9Y_-tEvfvSLHwX_4Yl63k9o_qH_GvBf28_hGa4_jzyaSQ</recordid><startdate>20180117</startdate><enddate>20180117</enddate><creator>Sicre de Fontbrune, Flore</creator><creator>Arnaud, Cécile</creator><creator>Cheminant, Morgane</creator><creator>Boulay, Aude</creator><creator>Konopacki, Johana</creator><creator>Lapusan, Simona</creator><creator>Robin, Christine</creator><creator>Bernaudin, Françoise</creator><creator>Suarez, Felipe</creator><creator>Simon, François</creator><creator>Socié, Gérard</creator><creator>Colin de Verdière, Nathalie</creator><creator>Consigny, Paul-Henri</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180117</creationdate><title>Immunogenicity and Safety of Yellow Fever Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients After Withdrawal of Immunosuppressive Therapy</title><author>Sicre de Fontbrune, Flore ; Arnaud, Cécile ; Cheminant, Morgane ; Boulay, Aude ; Konopacki, Johana ; Lapusan, Simona ; Robin, Christine ; Bernaudin, Françoise ; Suarez, Felipe ; Simon, François ; Socié, Gérard ; Colin de Verdière, Nathalie ; Consigny, Paul-Henri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-a8b0775d5dda02a2e61b62346e221e29ca1a8008121587d541ecedbeacec391a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sicre de Fontbrune, Flore</creatorcontrib><creatorcontrib>Arnaud, Cécile</creatorcontrib><creatorcontrib>Cheminant, Morgane</creatorcontrib><creatorcontrib>Boulay, Aude</creatorcontrib><creatorcontrib>Konopacki, Johana</creatorcontrib><creatorcontrib>Lapusan, Simona</creatorcontrib><creatorcontrib>Robin, Christine</creatorcontrib><creatorcontrib>Bernaudin, Françoise</creatorcontrib><creatorcontrib>Suarez, Felipe</creatorcontrib><creatorcontrib>Simon, François</creatorcontrib><creatorcontrib>Socié, Gérard</creatorcontrib><creatorcontrib>Colin de Verdière, Nathalie</creatorcontrib><creatorcontrib>Consigny, Paul-Henri</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sicre de Fontbrune, Flore</au><au>Arnaud, Cécile</au><au>Cheminant, Morgane</au><au>Boulay, Aude</au><au>Konopacki, Johana</au><au>Lapusan, Simona</au><au>Robin, Christine</au><au>Bernaudin, Françoise</au><au>Suarez, Felipe</au><au>Simon, François</au><au>Socié, Gérard</au><au>Colin de Verdière, Nathalie</au><au>Consigny, Paul-Henri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunogenicity and Safety of Yellow Fever Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients After Withdrawal of Immunosuppressive Therapy</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2018-01-17</date><risdate>2018</risdate><volume>217</volume><issue>3</issue><spage>494</spage><epage>497</epage><pages>494-497</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Yellow fever (YF) vaccine appears safe and immunogenic in selected hematopoietic stem cell transplant recipients. Persistent immunity to YF vaccine is observed in some patients vaccinated before transplantation and/or vaccinated with an immunized donor. Immunity to YF should be evaluated prior to vaccination.
Abstract
As a live attenuated vaccine, yellow fever vaccine (YFV) is not routinely performed after allogeneic hematopoietic stem cell transplant (HSCT) despite it being the only efficient preventive therapy. We retrospectively identified 21 HSCT recipients immunized with YFV at a median of 39 months after HSCT and a median of 33 months after withdrawal of immunosuppression without any side effects. Eighteen evaluable patients had protective immunity after YFV. We also observed that a third of the recipients vaccinated with YFV before HSCT had persistent protective immunity after HSCT.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>29087520</pmid><doi>10.1093/infdis/jix564</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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title | Immunogenicity and Safety of Yellow Fever Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients After Withdrawal of Immunosuppressive Therapy |
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