Curcumin and other dietary polyphenols: potential mechanisms of metabolic actions and therapy for diabetes and obesity

Recent controversy regarding the therapeutic potential of curcumin indicates the challenges to research in this field. Here, we highlight the investigations of curcumin and other plant-derived polyphenols that demonstrate their application to metabolic diseases, in particular, obesity and diabetes....

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2018-03, Vol.314 (3), p.E201-E205
Main Authors: Jin, Tianru, Song, Zhuolun, Weng, Jianping, Fantus, I George
Format: Article
Language:English
Subjects:
Animal models
Animals
Body weight
Body weight gain
Curcumin
Curcumin - pharmacology
Curcumin - therapeutic use
Diabetes
Diabetes mellitus
Diabetes Mellitus - metabolism
Diabetes Mellitus - therapy
Diet
Energy Metabolism - drug effects
Humans
Insulin
Insulin Resistance - physiology
Intestinal microflora
Metabolic disorders
Metabolism
Metabolites
Microbiota
Obesity
Obesity - metabolism
Obesity - therapy
Phytotherapy - methods
Plants
Polyphenols
Polyphenols - pharmacology
Polyphenols - therapeutic use
Signal Transduction - drug effects
Therapy
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Summary:Recent controversy regarding the therapeutic potential of curcumin indicates the challenges to research in this field. Here, we highlight the investigations of curcumin and other plant-derived polyphenols that demonstrate their application to metabolic diseases, in particular, obesity and diabetes. Thus, a number of preclinical and clinical investigations have shown the beneficial effect of curcumin (and other dietary polyphenols) in attenuating body weight gain, improving insulin sensitivity, and preventing diabetes development in rodent models and prediabetic subjects. Other intervention studies with dietary polyphenols have also found improvements in insulin resistance. Recent studies suggest that the metabolic effects of curcumin/polyphenols are linked to changes in the gut microbiota. Thus, research into curcumin continues to provide novel insights into metabolic regulation that may ultimately translate into effective therapy.
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.00285.2017