Reconstitution of T and NK cells after haploidentical hematopoietic cell transplantation using αβ T cell–depleted grafts and the clinical implication of γδ T cells

To investigate reconstitution of T and NK cells after αβ T lymphocyte–depleted haploidentical hematopoietic cell transplantation (HHCT) and the clinical implications of γδ T cells, we analyzed 50 pediatric patients who received 55 HHCTs using αβ T cell–depleted grafts. The number of CD3+ T cells and...

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Bibliographic Details
Published in:Clinical transplantation 2018-01, Vol.32 (1), p.n/a
Main Authors: Park, Meerim, Im, Ho Joon, Lee, Yu‐Jin, Park, Nuree, Jang, Seongsoo, Kwon, Seog Woon, Park, Chan‐Jeoung, Choi, Eun Seok, Koh, Kyung Nam, Seo, Jong Jin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child, Preschool
Female
Follow-Up Studies
Graft vs Host Disease - immunology
Graft vs Host Disease - prevention & control
haploidentical hematopoietic cell transplantation
Hematologic Neoplasms - immunology
Hematologic Neoplasms - therapy
Hematopoietic Stem Cell Transplantation - methods
Humans
Infant
Killer Cells, Natural - immunology
Lymphocyte Depletion - methods
Male
Prognosis
Receptors, Antigen, T-Cell, alpha-beta - metabolism
Receptors, Antigen, T-Cell, gamma-delta - metabolism
reconstitution
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
Tissue Donors
Transplantation Conditioning
Transplantation, Homologous
Young Adult
γδ T cell
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Summary:To investigate reconstitution of T and NK cells after αβ T lymphocyte–depleted haploidentical hematopoietic cell transplantation (HHCT) and the clinical implications of γδ T cells, we analyzed 50 pediatric patients who received 55 HHCTs using αβ T cell–depleted grafts. The number of CD3+ T cells and CD8+ T cells recovered rapidly and reached donor levels at days 180 and 60, respectively. Recovery of NK cells was rapid, and the median of NK cells at day 14 was comparable to the donor level. At day 14, median percentage of γδ T lymphocytes was 70.5%. After day 14, the percentage of γδ T cells gradually decreased, while the percentage of αβ T cells gradually increased. Patients with a low percentage (≤21%) of γδ T cells at day 30 had significantly higher incidence of cytomegalovirus (CMV) reactivation compared to patients with a high percentage (>70%) of γδ T cells (P 
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.13147