GLP-1 and IGF-I levels are elevated in late infancy in low birth weight infants, independently of GLP-1 receptor polymorphisms and neonatal nutrition

Low birth weight followed by rapid postnatal weight gain is associated with increased risks for obesity and diabetes in adulthood. Modulation of glucagon-like-peptide 1 (GLP-1) secretion by (epi)genetic mechanisms or nutrition may, in part, influence this risk. Formula-fed infants born small-for-ges...

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Bibliographic Details
Published in:International Journal of Obesity 2018-04, Vol.42 (4), p.915-918
Main Authors: Díaz, M, García-Beltran, C, López-Bermejo, A, de Zegher, F, Ibáñez, L
Format: Article
Language:English
Subjects:
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Age
Birth weight
Body composition
Body weight gain
Childbirth & labor
Diabetes
Diabetes mellitus
Energy balance
Epidemiology
Gastrointestinal hormones
Genetic aspects
Genetic polymorphisms
Genotypes
Glucagon
Growth factors
Health aspects
Health Promotion and Disease Prevention
Homeostasis
Hypothalamus
Infants
Insulin
Insulin-like growth factor I
Insulin-like growth factors
Internal Medicine
Low birth weight
Medicine
Medicine & Public Health
Metabolic Diseases
Neonates
Nuclei
Nutrition
Obesity
Public Health
Risk factors
Secretion
short-communication
Small for gestational age
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Summary:Low birth weight followed by rapid postnatal weight gain is associated with increased risks for obesity and diabetes in adulthood. Modulation of glucagon-like-peptide 1 (GLP-1) secretion by (epi)genetic mechanisms or nutrition may, in part, influence this risk. Formula-fed infants born small-for-gestational-age (SGA) have higher circulating GLP-1 at age 4 months than breastfed SGA or appropriate-for-gestational-age (AGA) infants. Here we assessed GLP-1 concentrations in healthy AGA ( n =149) and SGA ( n =107) subjects at age 12 months and their association with endocrine-metabolic and body composition parameters and GLP-1 receptor ( GLP-1R) rs6923761 and rs3765467 polymorphisms. At birth, cord GLP-1 concentrations were comparable in AGA and SGA infants. At age 12 months, insulin-like growth factor I (IGF-I) and GLP-1 levels were higher than at birth; SGA infants displayed higher IGF-I and GLP-1 concentrations than AGA infants (both P
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2017.271