Analgesic properties of aqueous bark extract of Adansonia digitata in Wistar rats

The study investigated the analgesic effect of the aqueous extract of the bark of Adansonia digitata using Wistar rats. Thirty Wistar rats weighing between 150 and 170g of either sex were used for the study. Animal were picked randomly and grouped into six with each group made up of five animals (3...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2018-01, Vol.97, p.209-212
Main Authors: Owoyele, Bamidele V., Bakare, Ahmed O.
Format: Article
Language:English
Subjects:
Adansonia
Adansoniadigitata
Analgesia
Analgesics - isolation & purification
Analgesics - pharmacology
Animals
Female
Formalin
Hotplate
Male
Pain Measurement - drug effects
Pain Measurement - methods
Plant Bark
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Random Allocation
Rats
Rats, Wistar
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Summary:The study investigated the analgesic effect of the aqueous extract of the bark of Adansonia digitata using Wistar rats. Thirty Wistar rats weighing between 150 and 170g of either sex were used for the study. Animal were picked randomly and grouped into six with each group made up of five animals (3 females and 2 males). Oral administration of 10ml/kg of normal saline were given to control group; 5mg/kg of indomethacin to reference group; and 25mg/kg, 50mg/kg, 100mg/kg or 200mg/kg of aqueous extracts of Adansonia digitata to each of the test groups respectively.Hotplate and formalin paw-licking tests were used for nociceptive assessment. Animals treated with aqueous bark extract of Adansonia digitata showed significantly (p
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2017.10.079