Distinctiveness of the Roma population within CYP2B6 worldwide variation

To determine variation of CYP2B6 gene within the genetically specific Croatian Roma (Gypsy) population originating from India and to examine it in the worldwide perspective. Seven SNP loci (rs12721655, rs2279343, rs28399499, rs34097093, rs3745274, rs7260329 and rs8192709) were genotyped in 439 subje...

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Bibliographic Details
Published in:Pharmacogenomics 2017-11, Vol.18 (17), p.1575-1587
Main Authors: Tomas, Željka, Kuhanec, Antonija, Škarić-Jurić, Tatjana, Petranović, Matea Zajc, Narančić, Nina Smolej, Janićijević, Branka, Salihović, Marijana Peričić
Format: Article
Language:English
Subjects:
Abolition of slavery
Alleles
Asian Continental Ancestry Group - genetics
CYP2B6 gene
Cytochrome P-450 CYP2B6 - genetics
Deoxyribonucleic acid
Dialects
DNA
Drugs
Gene frequency
Gene Frequency - genetics
Genes
Genomes
Genomics
Genotype
Haplotypes
Humans
Leukemia
Metabolism
Plasma
Polymorphism
Polymorphism, Single Nucleotide - genetics
Population
Population studies
Romani people
Single-nucleotide polymorphism
Studies
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Summary:To determine variation of CYP2B6 gene within the genetically specific Croatian Roma (Gypsy) population originating from India and to examine it in the worldwide perspective. Seven SNP loci (rs12721655, rs2279343, rs28399499, rs34097093, rs3745274, rs7260329 and rs8192709) were genotyped in 439 subjects using Kompetitive Allele Specific PCR (KASP) method. The Croatian Roma took an outlying position in CYP2B6 variation from the worldwide perspective mainly due to their exceptionally high minor allele frequency (MAF) for rs8192709 (12.8%), and lower for rs2279343 (21.1%) compared with south Asian populations. This study provides the first data of several CYP2B6 polymorphisms in Roma population and indicates the need for systematic investigation of the most important pharmacogenes' variants in this large, transnationally isolated population worldwide.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs-2017-0105