Premorbid exercising in specific cognitive tasks prevents impairment of performance in parkinsonian monkeys

Abstract Adult Cebus apella monkeys were exposed to either one, two or four series of cognitive tasks that place a demand on working memory and inhibitory control (Spatial Delayed Response and Object Retrieval Detour), before administration of the neurotoxin 1-methyl-1-4-phenyl-1,2,3,6-tetrahydropyr...

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Bibliographic Details
Published in:Brain research 2007-02, Vol.1134 (1), p.180-186
Main Authors: Lipina, Sebastián J, Colombo, Jorge A
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Animals
Behavior Therapy - methods
Biological and medical sciences
Biomarkers - analysis
Biomarkers - metabolism
Brain injury
Cebus
Cebus apella
Cognition
Cognition Disorders - etiology
Cognition Disorders - prevention & control
Cognition Disorders - therapy
Cognitive Therapy - methods
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Progression
Dopamine - biosynthesis
Immunohistochemistry
Male
Medical sciences
Neurodegeneration
Neurology
Neuronal Plasticity - physiology
Neuropsychological Tests - standards
Organic mental disorders. Neuropsychology
Parkinsonian Disorders - complications
Parkinsonian Disorders - physiopathology
Parkinsonian Disorders - psychology
Parkinsonism
Primate brain
Primates
Psychology. Psychoanalysis. Psychiatry
Psychomotor Performance - drug effects
Psychomotor Performance - physiology
Psychopathology. Psychiatry
Recovery of Function - physiology
Substantia Nigra - drug effects
Substantia Nigra - pathology
Substantia Nigra - physiopathology
Tyrosine 3-Monooxygenase - analysis
Tyrosine 3-Monooxygenase - metabolism
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Summary:Abstract Adult Cebus apella monkeys were exposed to either one, two or four series of cognitive tasks that place a demand on working memory and inhibitory control (Spatial Delayed Response and Object Retrieval Detour), before administration of the neurotoxin 1-methyl-1-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Following MPTP treatment, monkeys receiving more than one series successfully reached criteria at delays similar to those attained during the pre-MPTP stage for the Spatial Delayed Response task and avoided increased perseveration in the Object Retrieval Detour task. Results provide evidence that protection towards a neurotoxin in specific cognitive performances can be increased by repeated exposure to task-specific cognitive demands and that motor and cognitive impairment following MPTP treatment can be effectively dissociated in primates.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2006.11.066