Abundance and localization of skeletal muscle-related erbB2 may stimulate tumour growth during initial stages of oral oncogenesis

ErbB2 and erbB3 transmembrane receptors, known to be associated with neuronal and skeletal muscle developmental function, seem to play an important role in human oral oncogenesis. This study was designed to determine gradual erbB2 and erbB3 expression in an experimental animal system of induced oral...

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Bibliographic Details
Published in:Journal of musculoskeletal & neuronal interactions 2007-04, Vol.7 (2), p.185-190
Main Authors: Vairaktaris, E, Moulavassili, P, Loukeri, S, Spyridonidou, S, Yapijakis, C, Vassiliou, S, Nkenke, E, Vylliotis, A, Papakosta, V, Lazaris, A, Patsouris, E
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - analysis
Biomarkers, Tumor - metabolism
Carcinogens - pharmacology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - physiopathology
Cricetinae
Immunohistochemistry
Male
Mesocricetus
Mouth Neoplasms - genetics
Mouth Neoplasms - metabolism
Mouth Neoplasms - physiopathology
Muscle, Skeletal - metabolism
Predictive Value of Tests
Receptor, ErbB-2 - analysis
Receptor, ErbB-2 - metabolism
Receptor, ErbB-3 - analysis
Receptor, ErbB-3 - metabolism
Up-Regulation - physiology
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Summary:ErbB2 and erbB3 transmembrane receptors, known to be associated with neuronal and skeletal muscle developmental function, seem to play an important role in human oral oncogenesis. This study was designed to determine gradual erbB2 and erbB3 expression in an experimental animal system of induced oral carcinogenesis in Syrian golden hamsters. Thirty-seven animals were divided into one control group (N=7) and three experimental groups (N=10 each one), which were treated with carcinogen 9,10-dimethyl-1,2-benzanthracene and sacrificed at 10, 14 and 19 weeks after treatment. The histological status of observed lesions in the three experimental groups corresponded well with tumour advancement (from oral mucosal dysplasia to moderately differentiated squamous cell carcinoma). Tissue sections ranging from normal mucosa to squamous cell carcinoma were studied using monoclonal antibodies against erbB2 and erbB3 proteins. Cytoplasmic erbB2 expression was gradually increased in pre-cancerous stages, remained stable in initial tumour stages and substantially decreased in moderately-differentiated carcinomas, suggesting that it may be useful as an early prognostic factor. On the contrary, erbB3 was not expressed at all either in normal or tumour tissue.
ISSN:1108-7161