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Transcriptional regulation of the Drosophila caudal homeobox gene by bHLH–PAS proteins
Caudal-related homeobox transcription factors are involved in the definition of the anteroposterior axis and intestinal development. Recent reports indicate that dysregulation of CDX1 and CDX2, the human homologues of Drosophila caudal, are associated with several types of cancer. Very little is kno...
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| Published in: | Biochimica et biophysica acta 2007, Vol.1769 (1), p.41-48 |
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| container_end_page | 48 |
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| container_title | Biochimica et biophysica acta |
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| creator | Choi, Yoon-Jeong Kwon, Eun-Jeong Park, Joung-Sun Kang, Ho-Sung Kim, Young-Shin Yoo, Mi-Ae |
| description | Caudal-related homeobox transcription factors are involved in the definition of the anteroposterior axis and intestinal development. Recent reports indicate that dysregulation of
CDX1 and
CDX2, the human homologues of
Drosophila caudal, are associated with several types of cancer. Very little is known, however, about the regulatory mechanisms that direct the
caudal-related homeobox gene expression. In this study, we have identified the binding sites for bHLH–PAS proteins, referred to as CNS midline element (CME), in the 5′-flanking region of the
Drosophila caudal gene. Analyses using transgenic flies carrying a
caudal-lacZ fusion gene bearing a wild-type or mutant CME indicate that the CME sites are required for
caudal gene expression in vivo. We also determined that the
caudal promoter activity can be regulated by Trachealess (Trh)/Tango (Tgo) bHLH–PAS proteins, via the CME sites. Our results suggest that the
Drosophila caudal gene is a target of the Trh/Tgo bHLH–PAS proteins. |
| doi_str_mv | 10.1016/j.bbaexp.2006.11.008 |
| format | article |
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CDX1 and
CDX2, the human homologues of
Drosophila caudal, are associated with several types of cancer. Very little is known, however, about the regulatory mechanisms that direct the
caudal-related homeobox gene expression. In this study, we have identified the binding sites for bHLH–PAS proteins, referred to as CNS midline element (CME), in the 5′-flanking region of the
Drosophila caudal gene. Analyses using transgenic flies carrying a
caudal-lacZ fusion gene bearing a wild-type or mutant CME indicate that the CME sites are required for
caudal gene expression in vivo. We also determined that the
caudal promoter activity can be regulated by Trachealess (Trh)/Tango (Tgo) bHLH–PAS proteins, via the CME sites. Our results suggest that the
Drosophila caudal gene is a target of the Trh/Tgo bHLH–PAS proteins.</description><identifier>ISSN: 0167-4781</identifier><identifier>ISSN: 0006-3002</identifier><identifier>EISSN: 1879-2634</identifier><identifier>DOI: 10.1016/j.bbaexp.2006.11.008</identifier><identifier>PMID: 17207870</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Basic Helix-Loop-Helix Transcription Factors - pharmacology ; bHLH–PAS ; Caudal ; Drosophila ; Drosophila - genetics ; Drosophila Proteins - genetics ; Drosophila Proteins - pharmacology ; Embryo, Nonmammalian ; Gene Expression Regulation, Developmental ; Genes, Homeobox ; Homeodomain Proteins - genetics ; Transcription Factors - genetics ; Transcriptional regulation ; Transgenes</subject><ispartof>Biochimica et biophysica acta, 2007, Vol.1769 (1), p.41-48</ispartof><rights>2006 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-191eae47330c5b04d114cdbd93ec5146093e9688d65cc05c02084c2b79da3933</citedby><cites>FETCH-LOGICAL-c391t-191eae47330c5b04d114cdbd93ec5146093e9688d65cc05c02084c2b79da3933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17207870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Yoon-Jeong</creatorcontrib><creatorcontrib>Kwon, Eun-Jeong</creatorcontrib><creatorcontrib>Park, Joung-Sun</creatorcontrib><creatorcontrib>Kang, Ho-Sung</creatorcontrib><creatorcontrib>Kim, Young-Shin</creatorcontrib><creatorcontrib>Yoo, Mi-Ae</creatorcontrib><title>Transcriptional regulation of the Drosophila caudal homeobox gene by bHLH–PAS proteins</title><title>Biochimica et biophysica acta</title><addtitle>Biochim Biophys Acta</addtitle><description>Caudal-related homeobox transcription factors are involved in the definition of the anteroposterior axis and intestinal development. Recent reports indicate that dysregulation of
CDX1 and
CDX2, the human homologues of
Drosophila caudal, are associated with several types of cancer. Very little is known, however, about the regulatory mechanisms that direct the
caudal-related homeobox gene expression. In this study, we have identified the binding sites for bHLH–PAS proteins, referred to as CNS midline element (CME), in the 5′-flanking region of the
Drosophila caudal gene. Analyses using transgenic flies carrying a
caudal-lacZ fusion gene bearing a wild-type or mutant CME indicate that the CME sites are required for
caudal gene expression in vivo. We also determined that the
caudal promoter activity can be regulated by Trachealess (Trh)/Tango (Tgo) bHLH–PAS proteins, via the CME sites. Our results suggest that the
Drosophila caudal gene is a target of the Trh/Tgo bHLH–PAS proteins.</description><subject>Animals</subject><subject>Basic Helix-Loop-Helix Transcription Factors - pharmacology</subject><subject>bHLH–PAS</subject><subject>Caudal</subject><subject>Drosophila</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - pharmacology</subject><subject>Embryo, Nonmammalian</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, Homeobox</subject><subject>Homeodomain Proteins - genetics</subject><subject>Transcription Factors - genetics</subject><subject>Transcriptional regulation</subject><subject>Transgenes</subject><issn>0167-4781</issn><issn>0006-3002</issn><issn>1879-2634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkM2KFDEQgIMo7rj6BiI5ees21UknnYuwrD8jDCg4B28hSdfsZOjptEm37N58B9_QJzHDDHgT61JV8FUV9RHyElgNDOSbQ-2cxfupbhiTNUDNWPeIrKBTumokF4_JqmCqEqqDK_Is5wMrIUE-JVegGqY6xVbk2zbZMfsUpjnE0Q404d0y2FND447Oe6TvUsxx2ofBUm-XvjD7eMTo4j29wxGpe6BuvVn__vnry81XOqU4Yxjzc_JkZ4eMLy75mmw_vN_erqvN54-fbm82leca5go0oEWhOGe-dUz0AML3rtccfQtCslJo2XW9bL1nrWcN64RvnNK95Zrza_L6vLbc_b5gns0xZI_DYEeMSzay07LV_wGClowrEAUUZ9CXv3PCnZlSONr0YICZk3lzMGfz5mTeAJhivoy9uuxf3BH7v0MX1QV4ewaw2PgRMJnsA44e-5DQz6aP4d8X_gCpIpbz</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>Choi, Yoon-Jeong</creator><creator>Kwon, Eun-Jeong</creator><creator>Park, Joung-Sun</creator><creator>Kang, Ho-Sung</creator><creator>Kim, Young-Shin</creator><creator>Yoo, Mi-Ae</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>2007</creationdate><title>Transcriptional regulation of the Drosophila caudal homeobox gene by bHLH–PAS proteins</title><author>Choi, Yoon-Jeong ; Kwon, Eun-Jeong ; Park, Joung-Sun ; Kang, Ho-Sung ; Kim, Young-Shin ; Yoo, Mi-Ae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-191eae47330c5b04d114cdbd93ec5146093e9688d65cc05c02084c2b79da3933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Basic Helix-Loop-Helix Transcription Factors - pharmacology</topic><topic>bHLH–PAS</topic><topic>Caudal</topic><topic>Drosophila</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - pharmacology</topic><topic>Embryo, Nonmammalian</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, Homeobox</topic><topic>Homeodomain Proteins - genetics</topic><topic>Transcription Factors - genetics</topic><topic>Transcriptional regulation</topic><topic>Transgenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Yoon-Jeong</creatorcontrib><creatorcontrib>Kwon, Eun-Jeong</creatorcontrib><creatorcontrib>Park, Joung-Sun</creatorcontrib><creatorcontrib>Kang, Ho-Sung</creatorcontrib><creatorcontrib>Kim, Young-Shin</creatorcontrib><creatorcontrib>Yoo, Mi-Ae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimica et biophysica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Yoon-Jeong</au><au>Kwon, Eun-Jeong</au><au>Park, Joung-Sun</au><au>Kang, Ho-Sung</au><au>Kim, Young-Shin</au><au>Yoo, Mi-Ae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptional regulation of the Drosophila caudal homeobox gene by bHLH–PAS proteins</atitle><jtitle>Biochimica et biophysica acta</jtitle><addtitle>Biochim Biophys Acta</addtitle><date>2007</date><risdate>2007</risdate><volume>1769</volume><issue>1</issue><spage>41</spage><epage>48</epage><pages>41-48</pages><issn>0167-4781</issn><issn>0006-3002</issn><eissn>1879-2634</eissn><abstract>Caudal-related homeobox transcription factors are involved in the definition of the anteroposterior axis and intestinal development. Recent reports indicate that dysregulation of
CDX1 and
CDX2, the human homologues of
Drosophila caudal, are associated with several types of cancer. Very little is known, however, about the regulatory mechanisms that direct the
caudal-related homeobox gene expression. In this study, we have identified the binding sites for bHLH–PAS proteins, referred to as CNS midline element (CME), in the 5′-flanking region of the
Drosophila caudal gene. Analyses using transgenic flies carrying a
caudal-lacZ fusion gene bearing a wild-type or mutant CME indicate that the CME sites are required for
caudal gene expression in vivo. We also determined that the
caudal promoter activity can be regulated by Trachealess (Trh)/Tango (Tgo) bHLH–PAS proteins, via the CME sites. Our results suggest that the
Drosophila caudal gene is a target of the Trh/Tgo bHLH–PAS proteins.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17207870</pmid><doi>10.1016/j.bbaexp.2006.11.008</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biochimica et biophysica acta, 2007, Vol.1769 (1), p.41-48 |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Basic Helix-Loop-Helix Transcription Factors - pharmacology bHLH–PAS Caudal Drosophila Drosophila - genetics Drosophila Proteins - genetics Drosophila Proteins - pharmacology Embryo, Nonmammalian Gene Expression Regulation, Developmental Genes, Homeobox Homeodomain Proteins - genetics Transcription Factors - genetics Transcriptional regulation Transgenes |
| title | Transcriptional regulation of the Drosophila caudal homeobox gene by bHLH–PAS proteins |
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