Deficiency of central dopamine in multiple obesity models

The contribution of mesolimbic dopamine to the development of dietary obesity is not yet well understood. Because this system responds to feeding, dietary and/or genetic obesity could be linked to central dopamine deficiencies. In this study, we use inbred obesity-prone and obesity-resistant Sprague...

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Bibliographic Details
Published in:Appetite 2007-07, Vol.49 (1), p.293-293
Main Authors: Geiger, B.M., Frank, L.E., Caldera-siu, A.D., Stiles, L., Pothos, E.N.
Format: Article
Language:English
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Summary:The contribution of mesolimbic dopamine to the development of dietary obesity is not yet well understood. Because this system responds to feeding, dietary and/or genetic obesity could be linked to central dopamine deficiencies. In this study, we use inbred obesity-prone and obesity-resistant Sprague-Dawley adult female rats (Charles River Laboratories) to show that obesity-prone animals have lower basal extracellular dopamine levels in the nucleus accumbens shell in vivo (0.029±0.002 vs. 0.040±0.001 pg/sample, p
ISSN:0195-6663
1095-8304
DOI:10.1016/j.appet.2007.03.075