Fumonisin concentrations and in vivo toxicity of nixtamalized Fusarium verticillioides culture material: Evidence for fumonisin–matrix interactions

The toxic potential of nixtamalized foods can be underestimated if, during cooking, reversible fumonisin–food matrix interactions reduce the amount of mycotoxin that is detected but not the amount that is bioavailable. Fusarium verticillioides culture material (CM) was nixtamalized as is (NCM) or af...

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Bibliographic Details
Published in:Food and chemical toxicology 2008-08, Vol.46 (8), p.2841-2848
Main Authors: Burns, T.D., Snook, M.E., Riley, R.T., Voss, K.A.
Format: Article
Language:English
Subjects:
adverse effects
Alkalies
animal models
Animals
Apoptosis - drug effects
Bioavailability
Biological and medical sciences
Body Weight - drug effects
Chromatography, High Pressure Liquid
Cooking
corn meal
Diet
Eating
food contamination
food matrix
food processing quality
Fumonisin
fumonisins
Fumonisins - analysis
Fumonisins - toxicity
Fusarium - chemistry
Fusarium verticillioides
Gibberella fujikuroi
human diseases
Indicators and Reagents
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Kidney Diseases - chemically induced
Kidney Diseases - pathology
kidneys
lesions (animal)
Male
Medical sciences
Nixtamalization
Organ Size - drug effects
Plant poisons toxicology
Rats
Rats, Sprague-Dawley
Solvents
sphinganine
Sphingolipids - analysis
Sphingolipids - metabolism
Toxicity
Toxicology
Zea mays - chemistry
Zea mays - toxicity
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Summary:The toxic potential of nixtamalized foods can be underestimated if, during cooking, reversible fumonisin–food matrix interactions reduce the amount of mycotoxin that is detected but not the amount that is bioavailable. Fusarium verticillioides culture material (CM) was nixtamalized as is (NCM) or after mixing with ground corn (NCMC). Additional portions were sham nixtamalized without (SCM) or with corn (SCMC). Nixtamalization and sham nixtamalization reduced FB 1; CM, NCM, and SCM diets contained 9.08, 2.08, and 1.19 ppm, respectively. FB 1 was further reduced in the NCMC (0.49 ppm) but not the SCMC (1.01 ppm) diets compared to their NCM and SCM counterparts. Equivalent weights of the cooked products, uncooked CM, corn (UC) or nixtamalized UC (NUC) were fed to rats for up to three weeks. Kidney lesions in the NCM-fed group were less severe than in the CM-fed, positive control group and no lesions were found in the NCMC and other groups. Group kidney sphinganine (biomarker of fumonisin exposure) concentrations decreased in the order: CM (absolute concentration (nmol/g) = 600–800) > NCM (400–600) > SCM and SCMC (30–90) > NCMC, UC and NUC (
ISSN:0278-6915
1873-6351
DOI:10.1016/j.fct.2008.05.017