IFN gamma synergizes with IL-1ss to up-regulate MMP-9 secretion in a cellular model of central nervous system tuberculosis

Matrix metalloproteinase-9 (MMP-9) activity is implicated in pathogenesis of central nervous system tuberculosis (CNS-TB). IFN gamma , a key cytokine in TB, usually inhibits MMP-9 secretion. Addition of IFN gamma to conditioned media from M. tb-infected monocytes (CoMTB) resulted in a 7-fold increas...

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Bibliographic Details
Published in:The FASEB journal 2007-02, Vol.21 (2), p.356-365
Main Authors: Harris, JE, Fernandez-Vilaseca, M, Elkington, PTG, Horncastle, DE, Graeber, M B, Friedland, J S
Format: Article
Language:English
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Summary:Matrix metalloproteinase-9 (MMP-9) activity is implicated in pathogenesis of central nervous system tuberculosis (CNS-TB). IFN gamma , a key cytokine in TB, usually inhibits MMP-9 secretion. Addition of IFN gamma to conditioned media from M. tb-infected monocytes (CoMTB) resulted in a 7-fold increase in MMP-9 activity detected by gelatin zymography (P
ISSN:0892-6638
DOI:10.1096/fj.06-6925com