25OH vitamin D levels in pediatric patients affected by Prader–Willi syndrome

Purpose Obesity, insulin resistance, and puberty seem to influence and been inversely associated with 25-hydroxy vitamin D (25OHD) levels. To our knowledge, a study on 25OHD in children and adolescents with Prader–Willi syndrome (PWS), a genetic form of obesity, is not yet available. Objective To an...

Full description

Saved in:
Bibliographic Details
Published in:Journal of endocrinological investigation 2018-06, Vol.41 (6), p.739-742
Main Authors: Fintini, D., Pedicelli, S., Bocchini, S., Bizzarri, C., Grugni, G., Cappa, M., Crinò, A.
Format: Article
Language:English
Subjects:
Adolescents
Body composition
Body fat
Bone composition
Bone mass
Bone mineral density
Calcium
Children
Dual energy X-ray absorptiometry
Endocrinology
Growth hormones
Insulin
Medicine
Medicine & Public Health
Metabolic Diseases
Obesity
Pediatrics
Prader-Willi syndrome
Puberty
Rapid Communication
Vitamin D
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Obesity, insulin resistance, and puberty seem to influence and been inversely associated with 25-hydroxy vitamin D (25OHD) levels. To our knowledge, a study on 25OHD in children and adolescents with Prader–Willi syndrome (PWS), a genetic form of obesity, is not yet available. Objective To analyze the 25OHD values in pediatric PWS subjects in comparison with a control group (CNT), highlighting the possible correlations with IR, BMD, body composition, pubertal stage, and GH therapy (GHT). Methods Auxological and laboratory parameters, HOMA-IR, Vitamin D status, and bone density and body composition by DEXA scan were analyzed in 52 PWS and 110 controls (CNT), gender-, age-, and BMI-SD matched. None of them was on calcium or vitamin D. 20 PWS were on growth hormone (GH) therapy and 32 were previously treated. Results and conclusion Altogether, PWS had similar values of 25OHD compared to CNT.16 PWS (30.7%) and 27 CNT (24.5%) had low 25OHD levels (
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-017-0781-0