Monitoring the estimated glomerular filtration rate (eGFR) in patients with small-cell lung cancer during chemotherapy: equations based on serum creatinine or cystatin C?

• Published in: International journal of clinical oncology 2018-04, Vol.23 (2), p.258-265
• Main Authors: Tian, Xue, Zhang, Xinxing, Yu, Min, Lu, You, Ding, Zhenyu, Huang, Meijuan, Peng, Feng, Ren, Li, Wang, Jin, Wang, Yongsheng, Xu, Yong, Zhu, Jiang, Zhou, Lin, Zhou, Xiaojuan, Deng, Min, Tang, Xin, Gong, Youling
• Format: Article
• Language: English
• Subjects: Body mass index; Cancer Research; Chemotherapy; Creatinine; Cystatin C; Epidemiology; Epidermal growth factor receptors; Glomerular filtration rate; Kidney transplantation; Lung cancer; Mathematical models; Medicine; Medicine & Public Health; Oncology; Original Article; Patients; Renal function; Small cell lung carcinoma; Surgical Oncology
• ISSN: 1341-9625; 1437-7772
• DOI: 10.1007/s10147-017-1206-y

Background This study compared the differences between the estimated glomerular filtration rate (eGFR) calculated by several equations based on serum creatinine (Scr) and cystatin C (CysC) concentrations for monitoring renal function in patients with small-cell lung cancer (SCLC) during chemotherapy. Methods Seventy-one patients with SCLC were retrospectively analyzed. The eGFR before and after each chemotherapy cycle was calculated by the following equations: the chronic kidney disease epidemiology collaboration (CKD-EPI) equation, the modification of diet in renal disease (MDRD) equation, the Cockcroft–Gault (CG) equation, and five CysC-based equations. The patients were compared among the different eGFR groups. Results The mean decreases in eGFR CKD-EPI (−2.25 ± 9.89 ml/min/1.73 m 2 ) between each treatment cycle were more significant than the decreases in eGFR CG (−0.46 ± 10.17 ml/min/1.73 m 2 ), eGFR MDRD (−0.48 ± 9.79 ml/min/1.73 m 2 ), and five calculated eGFR CysC ( p  23) and receiving more treatment cycles (>3) were at increased risk for developing renal impairment with an eGFR less than 60 ml/min/1.73 m 2 during chemotherapy. Conclusions The eGFR calculated by the CKD-EPI equation changed more significantly between each chemotherapy cycle than did the eGFR from the other equations based on Scr or CysC in patients with SCLC. Oncologists should pay more attention to the renal function of specific patient groups during treatment.