The prognostic value of cancer stem-like cell markers SOX2 and CD133 in stage III colon cancer is modified by expression of the immune-related markers FoxP3, PD-L1 and CD3

Cancer stem-like cells are highly tumourigenic cells that can repopulate entire tumours after apparent successful treatment. Recent evidence suggests they interact with other cells in the tumour microenvironment, including immune cell subsets, to enhance their survival. The aim of this study was to...

Full description

Saved in:
Bibliographic Details
Published in:Pathology 2017-12, Vol.49 (7), p.721-730
Main Authors: Miller, T.J., McCoy, M.J., Hemmings, C., Bulsara, M.K., Iacopetta, B., Platell, C.F.
Format: Article
Language:English
Subjects:
AC133 Antigen - metabolism
Aged
Aged, 80 and over
B7-H1 Antigen - metabolism
Biomarkers, Tumor - metabolism
CD3 Complex - metabolism
Cohort Studies
Colon cancer
Colonic Neoplasms - diagnosis
Colonic Neoplasms - metabolism
Colonic Neoplasms - pathology
Female
Forkhead Transcription Factors - metabolism
FoxP3
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Male
Middle Aged
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
PD-L1
Prognosis
Proportional Hazards Models
Retrospective Studies
SOX2
SOXB1 Transcription Factors - metabolism
stem cell
Tissue Array Analysis
Tumor Microenvironment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cancer stem-like cells are highly tumourigenic cells that can repopulate entire tumours after apparent successful treatment. Recent evidence suggests they interact with other cells in the tumour microenvironment, including immune cell subsets, to enhance their survival. The aim of this study was to determine whether the expression of immune cell markers in primary colon cancer impacts the prognostic significance of cancer stem-like cell marker expression. Immunohistochemistry was used to assess the expression of putative stem cell markers (ALDH1, CD44v6, CD133, Lgr5, SOX2) and immune cell related markers (CD3, CD8, FoxP3, PD-L1) in 104 patients with stage III colon cancer. Associations of marker expression with overall and cancer-specific survival were determined using Kaplan–Meier analysis. High SOX2 expression in the central tumour area was found to be an independent factor for poor cancer-specific survival [hazard ratio (HR) 6.19; 95% confidence interval (CI) 2.24–17.14; p=0.001]. When immune-related factors were taken into account, patients categorised as SOX2low/FoxP3high had good outcome (HR 0.164; 95%CI 0.066–0.406; p
ISSN:0031-3025
1465-3931
DOI:10.1016/j.pathol.2017.08.007