Feasibility of rapid‐sequence 31 p magnetic resonance spectroscopy in cardiac patients

• Published in: Acta radiologica (1987) 2005-07, Vol.46 (4), p.386-390
• Main Authors: Chida, K., Otani, H., Saito, H., Nagasaka, T., Kagaya, Y., Kohzuki, M., Zuguchi, M., Shirato, K.
• Format: Article
• Language: English
• ISSN: 0284-1851; 1600-0455
• DOI: 10.1080/02841850510021283

Purpose: To determine the clinical feasibility of rapid‐sequence phosphorus‐31 magnetic resonance spectroscopy ( 31 P ‐MRS) of the heart with cardiac patients using a 1.5T clinical MR system. Material and Methods: Twenty cardiac patients, i.e. dilated cardiomyopathy (DCM) 13 cases, hypertrophic cardiomyopathy (HCM) 3 cases, hypertensive heart diseases (HHD) 3 cases, and aortic regurgitation (AR) 1 case were examined using rapid cardiac 31 P‐MRS. Complete three‐dimensional localization was performed using a two‐dimensional phosphorus chemical‐shift imaging sequence in combination with 30‐mm axial slice‐selective excitation. The rapid‐sequence 31 P‐MRS procedure was phase encoded in arrays of 8×8 steps with an average of 4 acquisitions. The total examination time, including proton imaging and shimming, for the rapid cardiac 31 P‐MRS procedure, ranged from 10 to 15 min, depending on the heart rate. Student's t test was used to compare creatine phosphate (PCr)/adenosine triphosphate (ATP) ratios from the cardiac patients with those of the control subjects ( n = 13). Results: The myocardial PCr/ATP ratio obtained by rapid 31 P‐MRS was significantly lower ( P