The Place of Antipsychotics in the Therapy of Anxiety Disorders and Obsessive-Compulsive Disorders

Purpose of Review The purpose of this review was to assess and present the findings up to this date on the efficacy of antipsychotics in the treatment of generalized anxiety disorders (GAD), social anxiety disorders (SAD), panic disorders (PD), and obsessive-compulsive disorders (OCD), mostly based...

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Bibliographic Details
Published in:Current psychiatry reports 2017-12, Vol.19 (12), p.103-103, Article 103
Main Authors: Pignon, Baptiste, Tezenas du Montcel, Chloé, Carton, Louise, Pelissolo, Antoine
Format: Article
Language:English
Subjects:
Antipsychotics
Anxiety disorders
Anxiety Disorders (A Pelissolo
Medicine
Medicine & Public Health
Neuroses
Obsessive compulsive disorder
Psychiatry
Psychotropic drugs
Section Editor
Topical Collection on Anxiety Disorders
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Summary:Purpose of Review The purpose of this review was to assess and present the findings up to this date on the efficacy of antipsychotics in the treatment of generalized anxiety disorders (GAD), social anxiety disorders (SAD), panic disorders (PD), and obsessive-compulsive disorders (OCD), mostly based on published randomized controlled trials (RCTs) or on open-label studies when RCT were lacking. Recent Findings Quetiapine could be recommended in patients with GAD. The efficacy of aripiprazole in two open-label studies on patients with antidepressant-refractory GAD should be assessed in RCTs. Despite preliminary positive results in open studies, there are currently no strong evidence for the effectiveness of antipsychotics in refractory SAD and in refractory PD. Conversely, risperidone and aripiprazole can be used for the treatment of refractory OCD as augmentation agents to antidepressants. Summary Contrary to SAD and PD, this review found evidence for the use of second-generation antipsychotics in GAD and OCD. Otherwise, first-generation antipsychotics cannot be recommended in anxiety disorders and OCD.
ISSN:1523-3812
1535-1645
DOI:10.1007/s11920-017-0847-x