PIM kinases: From survival factors to regulators of cell motility

[Display omitted] PIM kinases are oncogenic serine/threonine kinases, the expression and activities of which are tightly regulated in normal tissues, but upregulated in many types of human malignancies, including both hematological and solid cancers. Since high PIM expression levels have been connec...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2017-12, Vol.93, p.74-85
Main Authors: Santio, Niina M., Koskinen, Päivi J.
Format: Article
Language:English
Subjects:
Animals
Cancer
Cell Movement
Cell Proliferation
Humans
Invasion
Metastasis
Migration
Motility
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms - enzymology
Neoplasms - pathology
Neoplasms - therapy
PIM kinases
Proto-Oncogene Proteins c-pim-1 - genetics
Proto-Oncogene Proteins c-pim-1 - metabolism
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Summary:[Display omitted] PIM kinases are oncogenic serine/threonine kinases, the expression and activities of which are tightly regulated in normal tissues, but upregulated in many types of human malignancies, including both hematological and solid cancers. Since high PIM expression levels have been connected to cancer progression and poor patient survival, PIM kinases have become attractive targets for drug development. Many downstream targets have also been identified, through which PIM kinases promote cell survival, proliferation and metabolism. More recently, PIM kinases have been implicated in regulation of cell motility, which also plays an important role in tumor growth and cancer progression. This review summarizes effects of PIM kinases and their substrates especially on cancer cell migration, invasion and metastatic growth, based on data from cell-based assays, animal experiments and patients.
ISSN:1357-2725
1878-5875
DOI:10.1016/j.biocel.2017.10.016