Miniaturized high-performance liquid chromatography instrumentation

Miniaturized high performance liquid chromatography (HPLC) has attracted increasing attention for its potential in high-throughput analyses and point-of-care applications. In this review we highlight the recent advancements in HPLC system miniaturization. We focus on the major components that consti...

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Bibliographic Details
Published in:Talanta (Oxford) 2018-01, Vol.177, p.94-103
Main Authors: Lynch, Kyle B., Chen, Apeng, Liu, Shaorong
Format: Article
Language:English
Subjects:
Electroosmotic pump
Gradient generator
High performance liquid chromatography
Miniaturized
Nanoflow
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Summary:Miniaturized high performance liquid chromatography (HPLC) has attracted increasing attention for its potential in high-throughput analyses and point-of-care applications. In this review we highlight the recent advancements in HPLC system miniaturization. We focus on the major components that constitute these instruments along with their respective advantages and drawbacks as well as present a few representative miniaturized HPLC systems. We discuss briefly some of the applications and also anticipate the future development trends of these instrumental platforms. [Display omitted] •In this review, an overview of technology leading to miniaturization of an HPLC system is introduced.•Advancements in pumps, injectors, columns and detectors have led to a reduction in size.•Complete integrated and miniaturized systems, both commercial and academic, are presented.
ISSN:0039-9140
1873-3573
DOI:10.1016/j.talanta.2017.09.016