Organic CO Prodrugs Activated by Endogenous ROS

CO prodrugs with triggered release mechanisms are highly desirable for targeted delivery. Herein described are organic CO prodrugs that are activated by ROS and thus can be used to selectively deliver CO to cells with elevated ROS levels. Such CO prodrugs can serve as powerful tools for targeted del...

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Bibliographic Details
Published in:Organic letters 2018-01, Vol.20 (1), p.8-11
Main Authors: Pan, Zhixiang, Zhang, Jun, Ji, Kaili, Chittavong, Vayou, Ji, Xingyue, Wang, Binghe
Format: Article
Language:English
Subjects:
Drug Delivery Systems
Molecular Structure
Prodrugs
Reactive Oxygen Species - chemistry
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Summary:CO prodrugs with triggered release mechanisms are highly desirable for targeted delivery. Herein described are organic CO prodrugs that are activated by ROS and thus can be used to selectively deliver CO to cells with elevated ROS levels. Such CO prodrugs can serve as powerful tools for targeted delivery to disease sites with elevated ROS levels and to explore the therapeutic applications of CO.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b02775