MicroRNA profiles in neuroblastoma: Differences in risk and histology groups

Aim To determine the miRNA expression profiles of neuroblastomas with different clinical and histological characteristics. Methods In this study 24 samples from 17 patients, paraffin blocks were used. Their microRNA profiles were compared by five different analysis: analysis I: well‐poorly different...

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Bibliographic Details
Published in:Asia-Pacific journal of clinical oncology 2018-10, Vol.14 (5), p.e374-e379
Main Authors: Ergin, Kemal, Aktaş, Safiye, Altun, Zekiye, Dınız, Gülden, Olgun, Nur
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Cancer
Chemotherapy
ganglioneuroma
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Histology
Humans
microRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Neuroblastoma
Neuroblastoma - genetics
Neuroblastoma - pathology
Paraffin
Patients
Prognosis
Risk Factors
Risk groups
Survival Rate
Tumors
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Summary:Aim To determine the miRNA expression profiles of neuroblastomas with different clinical and histological characteristics. Methods In this study 24 samples from 17 patients, paraffin blocks were used. Their microRNA profiles were compared by five different analysis: analysis I: well‐poorly differentiated, analysis II: before–after chemotherapy, analysis III: favorable–unfavorable histology, analysis IV: neuroblastoma–ganglioneuroma, analysis V: low‐risk–middle‐risk–high risk groups. Clinical data were compared with differentially expressed microRNAs. Results It was found that 25 miRNAs between well‐poorly differentiated tumors, eight miRNAs before and after of the chemotherapy, three miRNAs between favorable and unfavorable histology, four miRNAs between neuroblastoma and ganglioneuroma, seven miRNAs between low and middle risk, one miRNA between middle and high risk, 14 miRNAs between low and high risk were differently expressed (P 
ISSN:1743-7555
1743-7563
DOI:10.1111/ajco.12821