Correlation of head‐up tilt table test time interval with future risk of recurrent syncope

Background Head‐up tilt table test (HUTT) is widely used for the investigation of syncope and presyncope. Time required for positive response has a probable relationship to the sensitivity of neural reflex mechanism underlying syncope. Methods We evaluated patients with history of syncope. Group A i...

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Bibliographic Details
Published in:Pacing and clinical electrophysiology 2017-12, Vol.40 (12), p.1462-1465
Main Authors: Singhania, Priti K, Ranwa, Bhanwar L., Gupta, Sajal
Format: Article
Language:English
Subjects:
Female
Humans
HUTT time interval
Male
Middle Aged
Recurrence
Risk Assessment
Syncope
Syncope - diagnosis
Tilt-Table Test
Time Factors
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Summary:Background Head‐up tilt table test (HUTT) is widely used for the investigation of syncope and presyncope. Time required for positive response has a probable relationship to the sensitivity of neural reflex mechanism underlying syncope. Methods We evaluated patients with history of syncope. Group A included patients with recurrent syncope defined as two or more episodes of syncope and group B included those with one episode of syncope. Time required for the test to become positive in both the groups was analyzed. Patients with positive HUTT were followed for 1 year. Results Of 80 patients, 68 eligible study patients were divided into group A (32.35%) and group B (67.65%). HUTT was positive in 41 patients (positivity rate  =  60.29%). Positivity rate was 100% in group A and 41.3% in group B. Median time interval for positive response in groups A and B were 12.5 and 30.0 minutes, respectively. An inverse association was found between recurrent syncope and time interval for positive response (R  =  − 0.282, P  =  0.002). Time interval of less than 19.5 minutes for positive response had 94.5% sensitivity and 97.89% specificity for recurrent syncope. On follow‐up, positive association was found between time interval for positive response less than 19.5 minutes and future recurrence of syncope (odds ratio  =  22.75, 95% confidence interval  =  4.37–118.34, P  =  0.000). Conclusion HUTT time interval of less than 19.5 minutes for positive response predicted future recurrence of syncope. Hence, it may serve as an important predictor of future recurrence of syncope.
ISSN:0147-8389
1540-8159
DOI:10.1111/pace.13219