The Relationship Between Clavien–Dindo Morbidity Classification and Oncologic Outcomes After Colorectal Cancer Resection

Background Limited data on the relationship between postoperative complications (POCs) after colorectal cancer resection and oncologic outcomes are available. We hypothesized that the increased severity of POCs is associated with progressively worse oncologic outcomes. Methods Patients with patholog...

Full description

Saved in:
Bibliographic Details
Published in:Annals of surgical oncology 2018-01, Vol.25 (1), p.188-196
Main Authors: Duraes, Leonardo C., Stocchi, Luca, Steele, Scott R., Kalady, Matthew F., Church, James M., Gorgun, Emre, Liska, David, Kessler, Hermann, Lavryk, Olga A., Delaney, Conor P.
Format: Article
Language:English
Subjects:
Abdominal Neoplasms
Adenocarcinoma
Age Factors
Aged
Classification
Colorectal Cancer
Colorectal carcinoma
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Digestive System Surgical Procedures - adverse effects
Disease-Free Survival
Female
Follow-Up Studies
Health Status
Humans
Length of Stay - statistics & numerical data
Male
Medicine
Medicine & Public Health
Middle Aged
Morbidity
Multivariate analysis
Neoplasm Recurrence, Local - epidemiology
Oncology
Patient Readmission - statistics & numerical data
Postoperative Complications - etiology
Reoperation - statistics & numerical data
Retrospective Studies
Severity of Illness Index
Surgery
Surgical Oncology
Survival
Survival Rate
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Limited data on the relationship between postoperative complications (POCs) after colorectal cancer resection and oncologic outcomes are available. We hypothesized that the increased severity of POCs is associated with progressively worse oncologic outcomes. Methods Patients with pathological stages I–III colorectal adenocarcinoma undergoing elective curative resection in a single institution between 2000 and 2012 were identified from a prospectively collected database. The severity of POCs was determined using the Clavien–Dindo classification, and oncologic outcomes were assessed. Results Of 2266 patients, 669 (30%) had at least one POC. POCs were not associated with pathologic stage ( p  = 0.58) or use of adjuvant therapy ( p  = 0.19). With a mean follow-up of 5.3 years, POCs were associated with decreased 5-year overall survival (OS) (60% vs. 77%, p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-017-6142-6