Design and synthesis of a novel class of dual PPAR^g/^d agonists

The design and synthesis of dual PPAR ^g/^d agonist (@@iR@)-3-{2-ethyl-4-[3- (4-ethyl-2-pyridin-2-yl-phenoxy)-butoxy]-phenyl}propionic acid is described. This compound dose-dependently lowered plasma glucose in hyperglycemic male Zucker diabetic fatty (ZDF) rats and produced less weight gain relativ...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2007-02, Vol.17 (4), p.1052-1055
Main Authors: Gonzalez, Isabel C, Lamar, Jason, Iradier, Fatima, Xu, Yanping, Winneroski, Leonard L, York, Jeremy, Yumibe, Nathan, Zink, Richard, Montrose-Rafizadeh, Chahrzad, Etgen, Gary J, Broderick, Carol L, Oldham, Brian A, Mantlo, Nathan
Format: Article
Language:English
Online Access:Get full text
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Summary:The design and synthesis of dual PPAR ^g/^d agonist (@@iR@)-3-{2-ethyl-4-[3- (4-ethyl-2-pyridin-2-yl-phenoxy)-butoxy]-phenyl}propionic acid is described. This compound dose-dependently lowered plasma glucose in hyperglycemic male Zucker diabetic fatty (ZDF) rats and produced less weight gain relative to rosiglitazone at an equivalent level of glucose control.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2006.11.029