Severe delayed haemolytic anaemia associated with artemether-lumefantrine treatment of malaria in a Japanese traveller

Delayed haemolytic anaemia has been reported in association with intravenous artesunate treatment in patients with severe Plasmodium falciparum malaria, and furthermore, oral artemisinin-based combination therapies including artemether-lumefantrine (AL) have also been incriminated. However, definite...

Full description

Saved in:
Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2018-03, Vol.24 (3), p.216-219
Main Authors: Hasegawa, Chihiro, Kudo, Masaharu, Maruyama, Haruhiko, Kimura, Mikio
Format: Article
Language:English
Subjects:
Administration, Intravenous
Administration, Oral
Anemia, Hemolytic - blood
Anemia, Hemolytic - chemically induced
Anemia, Hemolytic - drug therapy
Antimalarials - administration & dosage
Antimalarials - adverse effects
Artemether-lumefantrine
Artemisinins - administration & dosage
Artemisinins - adverse effects
Blackwater fever
Blackwater Fever - blood
Blackwater Fever - drug therapy
Blackwater Fever - etiology
Blackwater Fever - urine
Delayed haemolytic anaemia
Drug Therapy, Combination
Ethanolamines - administration & dosage
Ethanolamines - adverse effects
Fluorenes - administration & dosage
Fluorenes - adverse effects
High parasitaemia
Humans
Malaria, Falciparum - blood
Malaria, Falciparum - drug therapy
Male
Plasmodium falciparum
Plasmodium falciparum - isolation & purification
Plasmodium vivax - isolation & purification
Recurrence
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Delayed haemolytic anaemia has been reported in association with intravenous artesunate treatment in patients with severe Plasmodium falciparum malaria, and furthermore, oral artemisinin-based combination therapies including artemether-lumefantrine (AL) have also been incriminated. However, definite cases of delayed haemolytic anaemia associated with AL appear to be scarce, as reported cases were often treated concomitantly with other anti-malarials. In this study, we report a severe case of delayed haemolytic anaemia following AL alone in a Japanese traveller with severe parasitaemia caused by numerous P. falciparum parasites and a few P. vivax parasites. We also stress the need by further studies to differentiate between delayed haemolytic anaemia and blackwater fever, the latter being another malaria-related haemolytic condition, more clearly than they are now.
ISSN:1341-321X
1437-7780
DOI:10.1016/j.jiac.2017.10.008