A novel formulation of [6]-gingerol: Proliposomes with enhanced oral bioavailability and antitumor effect

[Display omitted] [6]-Gingerol, one of the components of the rhizome of Ginger, has a variety of biological activities such as anticoagulant, antioxidative, antitumor, anti-inflammatory, antihypertensive, and so forth. However, as one of the homologous phenolic ketones, [6]-gingerol is insoluble in...

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Bibliographic Details
Published in:International journal of pharmaceutics 2018-01, Vol.535 (1-2), p.308-315
Main Authors: Wang, Qilong, Wei, Qiuyu, Yang, Qiuxuan, Cao, Xia, Li, Qiang, Shi, Feng, Tong, Shan Shan, Feng, Chunlai, Yu, Qingtong, Yu, Jiangnan, Xu, Ximing
Format: Article
Language:English
Subjects:
Antitumor
Extraction
Gingerol
Proliposome
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Summary:[Display omitted] [6]-Gingerol, one of the components of the rhizome of Ginger, has a variety of biological activities such as anticoagulant, antioxidative, antitumor, anti-inflammatory, antihypertensive, and so forth. However, as one of the homologous phenolic ketones, [6]-gingerol is insoluble in water which limits its applications. Herein, we prepared [6]-gingerol proliposomes through modified thin-film dispersion method, which was spherical or oval, and physicochemically stable with narrow size distribution. Surprisingly, in vitro release of [6]-gingerol loaded proliposome compared with the free [6]-gingerol was significantly higher and its oral bioavailability increased 5-fold in vivo. Intriguingly, its antitumor effect was enhanced in the liposome formulation. Thus, our prepared [6]-gingerol proliposome proved to be a novel formulation for [6]-gingerol, which significantly improved its antitumor effect.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2017.11.006