Lower Trabecular Bone Score in Patients With Primary Aldosteronism: Human Skeletal Deterioration by Aldosterone Excess

• Published in: The journal of clinical endocrinology and metabolism 2018-02, Vol.103 (2), p.615-621
• Main Authors: Kim, Beom-Jun, Kwak, Mi Kyung, Ahn, Seong Hee, Kim, Hyeonmok, Lee, Seung Hun, Koh, Jung-Min
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon; Adrenal Gland Neoplasms - blood; Adrenal Gland Neoplasms - complications; Adult; Aged; Aldosterone; Aldosterone - blood; Blood pressure; Body mass index; Bone density; Bone Density - physiology; Bone mass; Bone mineral density; Bone turnover; Cancellous bone; Cancellous Bone - pathology; Cancellous Bone - physiology; Case-Control Studies; Endocrine disorders; Endocrinology; Female; Fractures; Humans; Hyperaldosteronism - blood; Hyperaldosteronism - complications; Hypertension; Hypokalemia; Male; Metabolism; Middle Aged; Osteoporosis - blood; Osteoporosis - etiology; Patients; Plasma; Risk Factors; Spine; Spine (lumbar); Statistical analysis
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2017-02043

Abstract Context Despite the potential detrimental effects of aldosterone excess on bone metabolism, discrepancies exist between fracture risk and bone mass in patients with and without primary aldosteronism (PA). Objective To clarify the possibility that aldosterone excess might mainly affect bone properties not explained by the bone mineral density (BMD). Design, Setting, and Patients Among 625 consecutive patients with newly diagnosed adrenal incidentaloma (AI), 72 with biochemically confirmed PA and 335 with nonfunctional AI were defined as cases and controls, respectively. Results In women, although no statistically significant differences in lumbar spine BMD were found between groups, the lumbar spine trabecular bone score (TBS) was significantly lower in patients with PA than in controls after adjustment for confounders (P = 0.007). Consistently, the plasma aldosterone concentration (PAC) correlated inversely with the lumbar spine TBS (P = 0.028) but not with bone mass in women. Compared with women in the lowest PAC quartile, those in the highest PAC quartile had significantly lower lumbar spine TBSs (P = 0.004). Importantly, all these observations in women remained statistically significant after additional adjustment for the lumbar spine BMD in the multivariable model. However, BMD and TBS at the lumbar spine did not differ according to the presence of PA and the level of PAC in men. Conclusion These findings provide clinical evidence that aldosterone excess in PA might contribute to deteriorated bone quality through weak microarchitecture, regardless of bone mass, especially in women. We have provided clinical evidence that aldosterone excess in PA might contribute to the deterioration of bone quality through weak microarchitecture, regardless of the bone mass.