Syngeneic and Xenogeneic Transplantations of Mesenchymal Stromal Cells Modify the Production of Reactive Oxygen Species by Blood Mononuclears of Mice

In vivo modifying effects of bone marrow mesenchymal stromal cells of humans and laboratory mice on ROS production by mouse blood mononuclears are studied by luminol-dependent zymosan-induced chemiluminescence after syngeneic and xenogeneic transplantation into systemic blood flow. The chemiluminesc...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-11, Vol.164 (1), p.80-84
Main Authors: Agaeva, E. V., Petrov, V. N., Konoplyannikov, A. G., Popovkina, O. E., Lepekhina, L. A., Sayapina, E. V., Semenkova, I. V.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Blood flow
Bone marrow
Cell activation
Cell Biology
Cells, Cultured
Chemiluminescence
Humans
Inflammation
Internal Medicine
Laboratory Medicine
Leukocytes (mononuclear)
Leukocytes, Mononuclear - metabolism
Macrophages
Macrophages - physiology
Mesenchymal Stem Cell Transplantation
Mesenchymal stem cells
Mesenchymal Stromal Cells - physiology
Mesenchyme
Mice
Pathology
Phagocytes
Phenotypes
Reactive oxygen species
Reactive Oxygen Species - metabolism
Stromal cells
Transplantation
Transplantation, Heterologous
Transplantation, Homologous
Xenografts
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Summary:In vivo modifying effects of bone marrow mesenchymal stromal cells of humans and laboratory mice on ROS production by mouse blood mononuclears are studied by luminol-dependent zymosan-induced chemiluminescence after syngeneic and xenogeneic transplantation into systemic blood flow. The chemiluminescent activity of mouse blood mononuclears has increased early (1 day) after syngeneic (mouse mesenchymal stromal cells) and xenogeneic (human mesenchymal stromal cells) transplantation. Later, 7-21 days after syngeneic and xenogeneic transplantation, the chemiluminescent activity of mouse mononuclears is suppressed. The probable mechanisms of involvement of the transplanted mesenchymal stromal cells in reprogramming of the blood mononuclear phagocytes from proinflammatory (M1) to anti-inflammatory (M2) phenotype under conditions of their in vivo interactions are discussed; a frequent manifestation of this reprogramming is transition of the phase of activation into inhibition of ROS-producing activity of macrophages.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3929-1