In-vitro release characteristics of tetracycline HCl, khellin and nicotinamide adenine dineculeotide from halloysite; a cylindrical mineral

The use of halloysite clay as a low cost alternative to more traditional microencapsulation systems is reported. Halloysite is an alumino-silicate clay which demonstrates a predominately cylindrical geometry, uniquely characterized by a hollow core or series of voids with diameters ranging from 16-5...

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Bibliographic Details
Published in:Journal of microencapsulation 2001-11, Vol.18 (6), p.713-722
Main Authors: PRICE, R. R, GABER, B. P, LVOV, Y
Format: Article
Language:English
Subjects:
Aluminum Silicates
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Capsules
Delayed-Action Preparations
Drug Compounding - methods
General pharmacology
In Vitro Techniques
Khellin - administration & dosage
Medical sciences
Microscopy, Electron
Microtubules Entrapment Controlled Delivery Microcylinders Microencapsulation
NAD - administration & dosage
Oxytetracycline - administration & dosage
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Summary:The use of halloysite clay as a low cost alternative to more traditional microencapsulation systems is reported. Halloysite is an alumino-silicate clay which demonstrates a predominately cylindrical geometry, uniquely characterized by a hollow core or series of voids with diameters ranging from 16-50 nm. These nanoscale-to-mesoscale microcylinders are capable of entrapping active agents within the core lumen as well as within any void spaces contained in the multilayered walls of the cylinder. Some of the active agents associated with the clay are also bound to the external surfaces of the clay. Delivery of the active agent is first by desorption of the active agent from the exterior surfaces and exposed ends of the microcylinders, and is followed by a second more prolonged phase dominated by pore diffusion from the ends of the cylinders. Halloysite is capable of retaining and releasing a range of active ingredients. Both hydrophilic and hydrophobic agents may be entrapped following appropriate pre-treatment of the clay to render it lipophilic. Here, a unique low cost alternative microcylindrical delivery system: the clay mineral halloysite, is investigated.
ISSN:0265-2048
1464-5246
DOI:10.1080/02652040010019532