Peripheral nerve ultrasound in Friedreich ataxia

ABSTRACT Introduction Sensory impairment in Friedreich ataxia (FRDA) is generally accepted as being due to a ganglionopathy. The degree of contribution from axonal pathology remains a matter of debate. Nerve ultrasound may be able to differentiate these processes. Methods The ultrasound cross‐sectio...

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Bibliographic Details
Published in:Muscle & nerve 2018-05, Vol.57 (5), p.852-856
Main Authors: Mulroy, Eoin, Pelosi, Luciana, Leadbetter, Ruth, Joshi, Purwa, Rodrigues, Miriam, Mossman, Stuart, Kilfoyle, Dean, Roxburgh, Richard
Format: Article
Language:English
Subjects:
Ataxia
cross‐sectional area
Friedreich ataxia
Friedreich's ataxia
Muscles
nerve ultrasound
Nerves
Patients
Peripheral nerves
sensory neuropathy
Ultrasonic imaging
Ultrasonic testing
Ultrasound
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Summary:ABSTRACT Introduction Sensory impairment in Friedreich ataxia (FRDA) is generally accepted as being due to a ganglionopathy. The degree of contribution from axonal pathology remains a matter of debate. Nerve ultrasound may be able to differentiate these processes. Methods The ultrasound cross‐sectional area of median, ulnar, tibial, and sural nerves of 8 patients with FRDA was compared with 8 age‐ and gender‐matched healthy controls and with reference values in our population. Results The nerves of the patients with FRDA were significantly larger than those of healthy controls at all upper limb sites (P 
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.26012