Arterial stiffness and cerebral hemodynamic pulsatility during cognitive engagement in younger and older adults

This study examined central artery stiffness and hemodynamic pulsatility during cognitive engagement in younger and older adults. Vascular-hemodynamic measures were completed in 19 younger (age 35±1yrs) and 20 older (age 69±2yrs) adults at rest and during a Stroop task. Aortic stiffness (carotid-fem...

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Bibliographic Details
Published in:Experimental gerontology 2018-01, Vol.101, p.54-62
Main Authors: Heffernan, Kevin S., Augustine, Jacqueline A., Lefferts, Wesley K., Spartano, Nicole L., Hughes, William E., Jorgensen, Randall S., Gump, Brooks B.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aging
Arterial stiffness
Blood flow
Blood pressure
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiopathology
Cerebrovascular Circulation
Cognition - physiology
Cognitive
Female
Humans
Male
Mental Status and Dementia Tests
Middle Cerebral Artery - diagnostic imaging
Middle Cerebral Artery - physiopathology
Pulsatile Flow
Pulse Wave Analysis - methods
Reaction Time - physiology
Stroop
Stroop Test
Ultrasonography, Doppler, Transcranial - methods
Vascular Stiffness
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Summary:This study examined central artery stiffness and hemodynamic pulsatility during cognitive engagement in younger and older adults. Vascular-hemodynamic measures were completed in 19 younger (age 35±1yrs) and 20 older (age 69±2yrs) adults at rest and during a Stroop task. Aortic stiffness (carotid-femoral pulse wave velocity, PWV) and carotid pulse pressure (PP) were assessed using applanation tonometry. Carotid stiffness was assessed as a single-point PWV using Doppler Ultrasound. Middle cerebral artery (MCA) mean flow and flow pulsatility index (PI) were assessed using transcranial Doppler. Cognitive function was assessed as accuracy and reaction time from the Stroop task. Older adults had lower accuracy scores and longer reaction times on the Stroop task compared to younger adults (p
ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2017.11.004