Cardiac involvement in the muscular dystrophies

ABSTRACT Cardiac disease is a common clinical manifestation present in a variety of neuromuscular disorders, most notably the muscular dystrophies. Heart disease may produce the presenting or predominant symptoms in these disorders but more often not does not result in clinical features at the time...

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Bibliographic Details
Published in:Muscle & nerve 2018-05, Vol.57 (5), p.707-715
Main Authors: Silvestri, Nicholas J., Ismail, Haisam, Zimetbaum, Peter, Raynor, Elizabeth M.
Format: Article
Language:English
Subjects:
bundle branch block
Cardiac arrhythmia
Cardiomyopathy
Conduction
Coronary artery disease
Disorders
Heart
Heart diseases
implantable cardioverter defibrillator
Muscles
muscular dystrophy
Myocardium
Neuromuscular diseases
sudden cardiac death
Ventricle
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Summary:ABSTRACT Cardiac disease is a common clinical manifestation present in a variety of neuromuscular disorders, most notably the muscular dystrophies. Heart disease may produce the presenting or predominant symptoms in these disorders but more often not does not result in clinical features at the time of initial presentation. Cardiac involvement in the muscular dystrophies results from pathologic changes in the myocardium and the cardiac conduction system, leading to cardiomyopathy and/or rhythm disturbances including supraventricular arrhythmias, life‐threatening ventricular arrhythmias, and sudden cardiac death. This Review covers the spectrum of cardiac dysfunction in these inherited muscle disorders and proposes practical recommendations for monitoring and management. Muscle Nerve 57: 707–715, 2018
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.26014