Vitamin D deficiency in children with recurrent respiratory infections, with or without immunoglobulin deficiency

• Published in: Advances in medical sciences 2018-03, Vol.63 (1), p.173-178
• Main Authors: Dąbrowska-Leonik, Nel, Bernatowska, Ewa, Pac, Małgorzata, Filipiuk, Wiktor, Mulawka, Jan, Pietrucha, Barbara, Heropolitańska-Pliszka, Edyta, Bernat-Sitarz, Katarzyna, Wolska-Kuśnierz, Beata, Mikołuć, Bożena
• Format: Article
• Language: English
• Subjects: Adolescent; Child; Child, Preschool; Female; Humans; Ig G; Immune system; Immunoglobulins; Immunoglobulins - deficiency; Infant; Male; Recurrence; Respiratory Tract Infections - blood; Respiratory Tract Infections - complications; Seasons; Vitamin D; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - complications
• ISSN: 1896-1126; 1898-4002
• DOI: 10.1016/j.advms.2017.08.001

The objective of this study was to evaluate thevitamin D concentration in patients with recurrent respiratory infections with or without immunoglobulin G, A or M (IgG, IgA, IgM) deficiency, and to find a correlation between the vitamin D concentration and the response to hepatitis B vaccination. The study involved 730 patients with recurrent respiratory infections. The concentration of 25-hydroxyvitamin D (25(OH)D), immunoglobulins G, A and M, anti-HBs was determined. The tests showed that 11% of patients presented IgG levels below the age related reference values. Children with reduced IgG concentration were also found to have significantly lower vitamin D concentrations in comparison to children with normal IgG. Vitamin D deficiency was observed in schoolchildren between 7 and 18 years of age. No correlation was found between 25(OH)D concentration and Hbs antibody levels. An investigation of a large group of patients who have recurrent infection found patients with IgG deficiency to whom special proceeding have to be performed: 1. Significantly lower vitamin D concentration observed in the group of children with IgG deficiency implicated in long-lasting monitoring of vitamin D level require adding to the practice guidelines for Central Europe 2013. 2. Intervention treatment with suitable doses of vitamin D to clarified metabolism of vitamin D has to be plan for children with IgG deficiency and significant lower vitamin D concentration.