Non‐alcoholic fatty liver disease and the development of reflux esophagitis: A cohort study

Background and Aim Non‐alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, is associated with gastroesophageal reflux disease in cross‐sectional studies, but a prospective association has not been evaluated. The current study aimed to determine whether NAFLD inc...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2018-05, Vol.33 (5), p.1053-1058
Main Authors: Min, Yang Won, Kim, Youngha, Gwak, Geum‐Youn, Gu, Seonhye, Kang, Danbee, Cho, Soo Jin, Guallar, Eliseo, Cho, Juhee, Sinn, Dong Hyun
Format: Article
Language:English
Subjects:
Body mass index
Cohort analysis
Confidence intervals
erosive esophagitis
Esophagitis
Fatty liver
Gastroesophageal reflux
Health risk assessment
Liver diseases
Metabolic syndrome
Metabolism
Mucosa
non‐alcoholic fatty liver disease
Sex ratio
Ultrasound
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Summary:Background and Aim Non‐alcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, is associated with gastroesophageal reflux disease in cross‐sectional studies, but a prospective association has not been evaluated. The current study aimed to determine whether NAFLD increases the risk of incident reflux esophagitis in a large cohort study. Methods We conducted a cohort study of 34 063 men and women without reflux esophagitis or other upper gastrointestinal disease at baseline who underwent health checkup examinations between January 2003 and December 2013. Fatty liver was diagnosed by ultrasound based on standard criteria. Reflux esophagitis was defined by the presence of at least grade A mucosal break on esophagogastroduodenoscopy. Results The prevalence of NAFLD at baseline was 33.2%. During 153 520.2 person‐years of follow‐up, the cumulative incidences of reflux esophagitis for participants without and with NAFLD were 9.6% and 13.8%, respectively (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.14042