Effects of intraoperative nutrients administration on energy expenditure during general anesthesia

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2018-01, Vol.45, p.37-40
• Main Authors: Satoh, Daizoh, Toda, Noriko, Yamamoto, Ichiro
• Format: Article
• Language: English
• Subjects: Acetic acid; Age; Aged; Amino acids; Amino Acids - administration & dosage; Anesthesia; Anesthesia, General; Blood Glucose - metabolism; Body Mass Index; Calorimetry; Calorimetry, Indirect; Cancer; Critical care; Diet; Energy expenditure; Energy measurement; Energy Metabolism; Esophageal Neoplasms - drug therapy; Esophageal Neoplasms - surgery; Esophagectomy; Esophagus; Female; Glucose; Glucose - administration & dosage; Hospitals; Humans; Intraoperative Care; Intubation; Length of Stay; Male; Metabolism; Micronutrients - administration & dosage; Middle Aged; Nitrogen; Nitrogen - blood; Nitrogen balance; Nutrients; Nutrition; Ostomy; Parenteral nutrition; Patients; Prospective Studies; Proteins; Resting energy expenditure; Surgery; Thorax; Ventilators
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2017.06.012

Recent reports have shown that intraoperative infusions of glucose and amino acids exert anticatabolic effects. The appropriate dosages of these amino acids and glucose during general anesthesia remain unknown. Patients who underwent esophagectomy for thoracic esophageal cancer were infused with acetated Ringer's solution that contained glucose and amino acids (B1 group [10 patients]: glucose, 3 g/h; amino acids, 1.2 g/h; B2 group [12 patients]: glucose, 4.5 g/h; amino acids, 1.8 g/h) or did not contain glucose and amino acids (C group, 10 patients). The measured energy expenditure was measured by indirect calorimetry. Nitrogen balance was measured during the anesthesia, and the lengths of the hospital stay were recorded. Resting energy expenditure (B1: 1230 ± 228; B2: 1317 ± 282; C: 1012 ± 153 kcal/h; B2 vs C, P