In vitro susceptibility of Microsporum canis and other dermatophyte isolates from veterinary infections during therapy with terbinafine or griseofulvin

We investigated the in vitro activity of terbinafine against fresh veterinary isolates of Microsporum canis and the potential of this organism to develop resistance in vivo during oral therapy. Dermatophyte cultures (n = 300) were obtained from naturally infected cats and dogs undergoing oral therap...

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Bibliographic Details
Published in:Medical mycology (Oxford) 2002-04, Vol.40 (2), p.179-183
Main Authors: Hofbauer, B, Leitner, I, Ryder, N S
Format: Article
Language:English
Subjects:
Microsporum canis
Microsporum gypseum
Trichophyton mentagrophytes
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Summary:We investigated the in vitro activity of terbinafine against fresh veterinary isolates of Microsporum canis and the potential of this organism to develop resistance in vivo during oral therapy. Dermatophyte cultures (n = 300) were obtained from naturally infected cats and dogs undergoing oral therapy with terbinafine or griseofulvin. M. canis comprised 92% of isolates; other species included Microsporum gypseum and Trichophyton mentagrophytes. Minimum inhibitory concentrations (MICs) and minimum fungicidal concentrations (MFCs) of terbinafine and griseofulvin were determined by broth macrodilution assay. Terbinafine was highly active against all three species with MIC sub(90)
ISSN:1369-3786
1460-2709
DOI:10.1080/136937802100312383