HPV genotype profile in a Norwegian cohort with ASC-US and LSIL cytology with three year cumulative risk of high grade cervical neoplasia

To explore the HPVgenotype profile in Norwegian women with ASC-US/LSIL cytology and the subsequent risk of high-grade cervical neoplasia (CIN 3+). In this observational study delayed triage of ASC-US/LSIL of 6058 women were included from 2005 to 2010. High-risk HPV detection with Hybrid Capture 2 (H...

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Bibliographic Details
Published in:Gynecologic oncology 2018-01, Vol.148 (1), p.111-117
Main Authors: Lie, A.K., Tropé, A., Skare, G.B., Bjørge, T., Jonassen, C.M., Brusegard, K., Lönnberg, S.
Format: Article
Language:English
Subjects:
Cumulative risk CIN3
HPV genotype profile
Secondary screening
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Summary:To explore the HPVgenotype profile in Norwegian women with ASC-US/LSIL cytology and the subsequent risk of high-grade cervical neoplasia (CIN 3+). In this observational study delayed triage of ASC-US/LSIL of 6058 women were included from 2005 to 2010. High-risk HPV detection with Hybrid Capture 2 (HC2) was used and the HC2+ cases were genotyped with in-house nmPCR. Women were followed-up for histologically confirmed CIN3+ within three years of index HPV test by linkage to the screening databases at the Cancer Registry of Norway. HC2 was positive in 45% (2756/6058) of the women. Within 3years CIN3+ was diagnosed in 26% of women20% for 13 high-risk genotypes as single infection
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2017.10.031