HPV genotype profile in a Norwegian cohort with ASC-US and LSIL cytology with three year cumulative risk of high grade cervical neoplasia

To explore the HPVgenotype profile in Norwegian women with ASC-US/LSIL cytology and the subsequent risk of high-grade cervical neoplasia (CIN 3+). In this observational study delayed triage of ASC-US/LSIL of 6058 women were included from 2005 to 2010. High-risk HPV detection with Hybrid Capture 2 (H...

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Published in:Gynecologic oncology 2018-01, Vol.148 (1), p.111-117
Main Authors: Lie, A.K., Tropé, A., Skare, G.B., Bjørge, T., Jonassen, C.M., Brusegard, K., Lönnberg, S.
Format: Article
Language:English
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Cumulative risk CIN3
HPV genotype profile
Secondary screening
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cited_by cdi_FETCH-LOGICAL-c359t-925b6b7b531efae1e67b9be580bb653b267bca31d3b98fccd749a383b0bc7eac3
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container_end_page 117
container_issue 1
container_start_page 111
container_title Gynecologic oncology
container_volume 148
creator Lie, A.K.
Tropé, A.
Skare, G.B.
Bjørge, T.
Jonassen, C.M.
Brusegard, K.
Lönnberg, S.
description To explore the HPVgenotype profile in Norwegian women with ASC-US/LSIL cytology and the subsequent risk of high-grade cervical neoplasia (CIN 3+). In this observational study delayed triage of ASC-US/LSIL of 6058 women were included from 2005 to 2010. High-risk HPV detection with Hybrid Capture 2 (HC2) was used and the HC2+ cases were genotyped with in-house nmPCR. Women were followed-up for histologically confirmed CIN3+ within three years of index HPV test by linkage to the screening databases at the Cancer Registry of Norway. HC2 was positive in 45% (2756/6058) of the women. Within 3years CIN3+ was diagnosed in 26% of women20% for 13 high-risk genotypes as single infection
doi_str_mv 10.1016/j.ygyno.2017.10.031
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subjects Cumulative risk CIN3
HPV genotype profile
Secondary screening
title HPV genotype profile in a Norwegian cohort with ASC-US and LSIL cytology with three year cumulative risk of high grade cervical neoplasia
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