Refining the Definitions of Biochemical and Clinical Cure for Primary Aldosteronism Using the Primary Aldosteronism Surgical Outcome (PASO) Classification System

Introduction Determination of outcomes after adrenalectomy for primary aldosteronism (PA) is limited by the lack of standardized definitions of cure. The Primary Aldosteronism Surgical Outcomes (PASO) group recently established new consensus definitions for biochemical and clinical cure of PA. We hy...

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Bibliographic Details
Published in:World journal of surgery 2018-02, Vol.42 (2), p.453-463
Main Authors: Miller, B. S., Turcu, A. F., Nanba, A. T., Hughes, D. T., Cohen, M. S., Gauger, P. G., Auchus, R. J.
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adrenalectomy
Aldosterone
Biochemistry
Cardiac Surgery
Criteria
Demographics
Endocrine disorders
General Surgery
Males
Medicine
Medicine & Public Health
Original Scientific Report
Patients
Surgery
Surgical outcomes
Thoracic Surgery
Vascular Surgery
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Summary:Introduction Determination of outcomes after adrenalectomy for primary aldosteronism (PA) is limited by the lack of standardized definitions of cure. The Primary Aldosteronism Surgical Outcomes (PASO) group recently established new consensus definitions for biochemical and clinical cure of PA. We hypothesize that utilization of PASO definitions will better stratify patient outcomes after surgery compared to original and current criteria utilized to document cure. Materials and Methods Patients undergoing adrenalectomy for PA from 1996 to 2016 were studied. Clinical data were reviewed. Three different sets of criteria (original, current, and PASO) were evaluated for differences in documentation of cure. Demographic data were reported as median (range). Comparisons were made using the Mann–Whitney U test; p  
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-017-4311-1