Antioxidant and anti-inflammatory properties of Ilex guayusa tea preparations: a comparison to Camellia sinensis teas

Ilex guayusa tea preparations are now commercially available as Runa tea. Little is known regarding the antioxidant and anti-inflammatory bioactivities of this tea. The I. guayusa teas had a total polyphenolic content between 54.39 and 67.23 mg GAE per g dry mass and peroxyl radical scavenging capac...

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Bibliographic Details
Published in:Food & function 2017-12, Vol.8 (12), p.4601-4610
Main Authors: Pardau, Madelein D, Pereira, Andreia S P, Apostolides, Zeno, Serem, June C, Bester, Megan J
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory agents
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Beverages - analysis
Caco-2 Cells
Camellia sinensis
Camellia sinensis - chemistry
Diet
Humans
Ilex guayusa - chemistry
Inflammation
Lipopolysaccharides
Macrophages - drug effects
Macrophages - immunology
Mass Spectrometry
Mass spectroscopy
Mice
Nitric oxide
Oxidation
Oxidative stress
Peroxyl radicals
Phenols
Phenols - chemistry
Phenols - pharmacology
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
RAW 264.7 Cells
Tea
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Summary:Ilex guayusa tea preparations are now commercially available as Runa tea. Little is known regarding the antioxidant and anti-inflammatory bioactivities of this tea. The I. guayusa teas had a total polyphenolic content between 54.39 and 67.23 mg GAE per g dry mass and peroxyl radical scavenging capacities between 1773.41 and 2019 μmol TE per g dry mass, nearly half of that for the Camellia sinensis teas. The I. guayusa teas afforded 60-80% protection from oxidative stress in the Caco-2 cellular antioxidant assay, comparable to the C. sinensis teas. The anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 cells of I. guayusa teas was similarly comparable to the C. sinensis teas with nitric oxide production reduced by 10-30%. Major compounds identified by mass spectrometry were the phenolic mono- and dicaffeoylquinic acid derivatives. I. guayusa teas are a good source of dietary phenolic compounds with cellular antioxidant and anti-inflammatory properties.
ISSN:2042-6496
2042-650X
DOI:10.1039/c7fo01067b