Long noncoding RNAs act as regulators of autophagy in cancer

[Display omitted] Long noncoding RNAs (lncRNAs) have emerged as critical regulators in various cellular processes. Studies have disclosed an important function of lncRNAs in the regulation of autophagy, a crucial cellular homeostatic mechanism that plays a pro-survival or pro-death role in cancer. D...

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Bibliographic Details
Published in:Pharmacological research 2018-03, Vol.129, p.151-155
Main Author: Sun, Ting
Format: Article
Language:English
Subjects:
Autophagy
Biomarker
Cancer
Humans
lncRNA
miRNA
Neoplasms - genetics
RNA, Long Noncoding
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Summary:[Display omitted] Long noncoding RNAs (lncRNAs) have emerged as critical regulators in various cellular processes. Studies have disclosed an important function of lncRNAs in the regulation of autophagy, a crucial cellular homeostatic mechanism that plays a pro-survival or pro-death role in cancer. Deregulation of lncRNAs can contribute to tumorigenesis and cancer progression, wherein lncRNAs can act as oncogenes or tumor suppressors. In this review, we highlight the recent advances in understanding the relationship between lncRNAs and autophagy regulation in cancer. Exploiting the newly emerging knowledge of the lncRNA-autophagy-cancer axis may provide novel targets for cancer therapy.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2017.11.009