Freeze-drying of silica nanoparticles: redispersibility toward nanomedicine applications

To study freeze-drying of silica nanoparticles (SiO NPs) in order to find suitable conditions to produce lyophilized powders with no aggregation after resuspension and storage. SiO NPs were synthesized using a Stöber-based procedure, and characterized by scanning electron microscopy, dynamic light s...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2018-01, Vol.13 (2), p.179-190
Main Authors: Picco, Agustin S, Ferreira, Larissa F, Liberato, Michelle S, Mondo, Gabriela B, Cardoso, Mateus B
Format: Article
Language:English
Subjects:
Ammonia
Carbohydrates
Carbohydrates - chemistry
colloidal stability
Drug Compounding
Drug Stability
Dynamic Light Scattering
Ethanol
Freeze Drying - methods
freeze-drying
Humans
inorganic nanoparticles
lyophilization
Nanomedicine
nanoparticle storage
Nanoparticles
Nanoparticles - chemistry
Particle Size
Powders
redispersibility
Scanning electron microscopy
silica
Silicon Dioxide - chemistry
Solubility
Surface Properties
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Summary:To study freeze-drying of silica nanoparticles (SiO NPs) in order to find suitable conditions to produce lyophilized powders with no aggregation after resuspension and storage. SiO NPs were synthesized using a Stöber-based procedure, and characterized by scanning electron microscopy, dynamic light scattering and nitrogen adsorption/desorption isotherms. SiO NPs hydrodynamic diameters were compared prior and after freeze-drying in the presence/absence of carbohydrate protectants. Glucose was found to be the most suitable protectant against the detrimental effects of lyophilization. The minimum concentration of carbohydrate required to effectively protect SiO NPs from aggregation during freeze-drying is influenced by the nanoparticle's size and texture. Negligible aggregation was observed during storage. Carbohydrates can be used during SiO NPs freeze-drying process to obtain redispersable solids that maintain original sizes without residual aggregation.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2017-0280